类风湿关节炎患者一级亲属的肌肉骨骼超声表现

IF 1 Q4 RHEUMATOLOGY
Safaa A. Hussein, Abdelazim M. El-Hefny, Caroline S. Morad, Bassant MI Hassanin, Mohamed RM Abdelkader
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引用次数: 0

摘要

目的:应用高分辨率超声检测类风湿关节炎(RA)患者健康一级亲属(FDRs)亚临床关节和/或肌腱病变的频率及其与血清学指标的关系。患者和方法:这项工作是在60名患关节炎的高风险受试者中进行的;RA患者的健康fdr临床评估,实验室检查和高分辨率肌肉骨骼超声(MSUS)。采用超声7 (US7)评分系统对临床优势足、手7个关节进行灰度和多普勒血流评价。US7评分评估了以下关节:手腕,掌指关节(MCP) II和III,近端指间关节(PIP) II和III,跖指关节(MTP) II和V,检查了腱鞘炎/腱鞘旁炎,滑膜炎和糜烂。结果:类风湿因子(RF)阳性4例(6.7%),抗环瓜氨酸肽(anti-CCP)抗体阳性2例(3.3%),MSUS阳性31例(51.6%);其中18人(58%)患有关节痛。灰度级滑膜炎是最常见的发现,31例fdr(51.6%)记录了滑膜炎,2例(3.3%)fdr存在腱鞘炎/腱鞘旁炎。所有受试者均未发现糜烂。腕部是23例(38.3%)MSUS患者中最常受影响的关节。RF给予最佳AUC(67%),其次是抗ccp(52%),最后是关节痛。结论:这项工作符合fdr是pre-RA的概念。MSUS作为一种有效的筛查工具,用于检测亚临床滑膜炎的危险个体。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Musculoskeletal ultrasound findings in first-degree relatives of rheumatoid arthritis patients
Aim of the work: To determine the frequency of subclinical joint and/or tendon affection using high resolution ultrasonography in healthy first-degree relatives (FDRs) of patients with rheumatoid arthritis (RA) and the relation to serological markers. Patients and methods: This work was conducted on 60 subjects with high risk of developing arthritis; healthy FDRs of patients with RA. Clinical assessment, laboratory investigations and high-resolution musculoskeletal ultrasound (MSUS) were done. Seven joints of the clinically dominant foot and hand had been evaluated by ultrasound in grayscale and Doppler flow employing the ultrasound 7 (US7) scoring system. The US7 score evaluated the following joints: wrists, metacarpophalangeal (MCP) II and III, proximal interphalangeal (PIP) II and III, and metatarsophalangeal (MTP) II and V, which had been examined for tenosynovitis/para-tenonitis, synovitis, and erosions. Results: Rheumatoid factor (RF) was positive in four FDRs (6.7%) had, two (3.3%) had positive anti-cyclic citrullinated peptide (anti-CCP) antibodies, MSUS positive findings had been identified in 31 FDRs (51.6%); of whom 18 (58%) had arthralgia. Synovitis by Gray Scale was the commonest finding, as it was recorded in 31 FDRs (51.6%), tenosynovitis/para-tenonitis was present in 2 (3.3%) FDRs. There were no erosions detected in all subjects. The wrist was the most frequently affected joint in 23 subjects (38.3%) on MSUS.RF gives the best AUC being (67%), followed by anti-CCP (52%), then the arthralgia. Conclusion: This work is in line with the notion of FDRs being pre-RA. MSUS serves as an effective screening instrument for detecting subclinical synovitis among at risk individuals.
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来源期刊
Egyptian Rheumatologist
Egyptian Rheumatologist RHEUMATOLOGY-
CiteScore
2.00
自引率
22.20%
发文量
77
审稿时长
39 weeks
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