水通道蛋白在神经退行性疾病中的新作用：药物开发的新靶点

IF 1.7 4区心理学 Q3 PSYCHOLOGY, BIOLOGICAL

Learning and Motivation Pub Date : 2025-02-01 DOI:10.1016/j.lmot.2024.102083

Mengzhen Zhou, Ruen Liu

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引用次数: 0

摘要

阿尔茨海默病患者的早期表现是学习和动力下降，健忘，尤其是刚刚发生的事情，他们变得被动，没有动力，对爱好失去兴趣。人们认为阿尔茨海默病的主要病理改变是β-淀粉样蛋白（Aβ）在大脑中的异常沉积和tau蛋白的磷酸化，各种体外和体内实验表明，水通道蛋白-4 （AQP4）可能参与阿尔茨海默病中Aβ的代谢和清除。目的明确AQP4的结构和功能，探讨AQP4在阿尔茨海默病中清除a β的作用及其可能机制，为阿尔茨海默病的诊断和治疗提供新的方向。结论AQP4对脑淋巴功能的调控作用增强，对阿尔茨海默病的发生、进展和转归具有重要影响。AQP4激动剂或诱导AQP4开放的药物有望成为阿尔茨海默病的新疗法。

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Emerging role of aquaporin in neurodegenerative diseases: A novel target for drug development

Background

The early manifestations of Alzheimer's patients are a decline in learning and motivation, forgetfulness, especially what has just happened, and they become passive, unmotivated, and lose interest in hobbies. It is believed that the main pathological changes in Alzheimer's disease are abnormal deposition of β-amyloid (Aβ) protein and phosphorylation of tau in the brain, and various in vitro and in vivo experiments have shown that aquaporin-4 (AQP4) may be responsible for Aβ metabolism and clearance in Alzheimer's disease.

Objective

To provide a new direction for the diagnosis and treatment of Alzheimer's disease by characterizing the structure and function of AQP4 and the function and possible mechanism of AQP4 in the clearance of Aβ in Alzheimer's disease.

Conclusion

Strengthening of the regulatory effect of AQP4 on lymphatic function in the brain has an important effect on the development, progression and outcome of Alzheimer's disease. AQP4 agonists or agents that induce AQP4 opening are expected to become novel treatments for Alzheimer's disease.

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来源期刊

Learning and Motivation Multiple-

CiteScore

2.90

自引率

0.00%

发文量

期刊介绍： Learning and Motivation features original experimental research devoted to the analysis of basic phenomena and mechanisms of learning, memory, and motivation. These studies, involving either animal or human subjects, examine behavioral, biological, and evolutionary influences on the learning and motivation processes, and often report on an integrated series of experiments that advance knowledge in this field. Theoretical papers and shorter reports are also considered.