通过单细胞测序，照亮细胞核的细胞生物学

IF 6 2区生物学 Q1 CELL BIOLOGY

Current Opinion in Cell Biology Pub Date : 2025-02-03 DOI:10.1016/j.ceb.2025.102468

Jeroen van den Berg , Peter Zeller

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引用次数: 0

摘要

从基因组完整性的保存到RNA翻译的调节，几乎所有的细胞过程都以细胞环境依赖的方式进行调节。为了充分了解所涉及的核过程的环境特异性功能，在过去十年中开发了大量的单细胞测序技术。这项仪器工作证明了细胞类型和单个细胞之间的异质性，带来了对核机制及其对细胞状态的串扰的新理解。在这篇综述中，我们将介绍新的技术进展及其令人兴奋的应用，以及未来发现新的核过程和它们之间的串扰的机会。

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Shining a light on cell biology of the nucleus with single-cell sequencing

From the preservation of genomic integrity to the regulation of RNA translation, nearly all cellular processes are regulated in a cell context-dependent manner. To fully understand the context-specific function of involved nuclear processes, a vast number of single-cell sequencing technologies were developed over the last decade. This instrumental work demonstrated the heterogeneity between cell types and individual cells, bringing about new understanding of nuclear mechanisms and their crosstalk to cell states. In this review, we will cover new technological advances and their exciting applications as well as future opportunities to discover new nuclear processes and the crosstalk between them.

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来源期刊

Current Opinion in Cell Biology 生物-细胞生物学

CiteScore

14.60

自引率

1.30%

发文量

审稿时长

93 days

期刊介绍： Current Opinion in Cell Biology (COCEBI) is a highly respected journal that specializes in publishing authoritative, comprehensive, and systematic reviews in the field of cell biology. The journal's primary aim is to provide a clear and readable synthesis of the latest advances in cell biology, helping specialists stay current with the rapidly evolving field. Expert authors contribute to the journal by annotating and highlighting the most significant papers from the extensive body of research published annually, offering valuable insights and saving time for readers by distilling key findings. COCEBI is part of the Current Opinion and Research (CO+RE) suite of journals, which leverages the legacy of editorial excellence, high impact, and global reach to ensure that the journal is a widely read resource integral to scientists' workflow. It is published by Elsevier, a publisher known for its commitment to excellence in scientific publishing and the communication of reproducible biomedical research aimed at improving human health. The journal's content is designed to be an invaluable resource for a diverse audience, including researchers, lecturers, teachers, professionals, policymakers, and students.