通过3-烯基-2-硫代喹啉-4-酮分子内的区域选择性亲电杂环合成2-功能化二氢噻唑[2,3-b]喹唑啉

IF 1.4 4区化学 Q4 CHEMISTRY, INORGANIC & NUCLEAR

Phosphorus, Sulfur, and Silicon and the Related Elements Pub Date : 2024-09-02 DOI:10.1080/10426507.2024.2416210

Diana Zh. Kut , Mykola M. Kut , Eugeniy M. Ostapchuk , Mikhajlo Yu. Onysko , Petro P. Onys’ko , Vasil G. Lendel

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引用次数: 0

摘要

由卤素、NBS、硫酰氯、质子酸、硒或卤化碲诱导的3-烯基-2-硫氧喹啉-4-酮分子内亲电杂环化具有高区域选择性。这一过程生成了2功能化的二氢噻唑[2,3-b]喹唑啉，显示了该合成路线在各种亲电试剂上的通用性和可靠性。

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Versatile synthesis of 2-functionalized dihydrothiazolo[2,3-b]quinazolines through regioselective electrophilic intramolecular heterocyclization of 3-alkenyl-2-thioxoquinazolin-4-ones

Electrophilic intramolecular heterocyclizations of 3-alkenyl-2-thioxoquinazolin-4-ones, induced by halogens, NBS, sulfuryl chloride, protic acids, selenium, or tellurium halides, proceed with high regioselectivity. This process leads to the formation of 2-functionalized dihydrothiazolo[2,3-b]quinazolines, showcasing the versatility and reliability of this synthetic route across various electrophilic reagents.

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来源期刊

Phosphorus, Sulfur, and Silicon and the Related Elements 化学-无机化学与核化学

CiteScore

2.60

自引率

7.70%

发文量

103

审稿时长

2.1 months

期刊介绍： Phosphorus, Sulfur, and Silicon and the Related Elements is a monthly publication intended to disseminate current trends and novel methods to those working in the broad and interdisciplinary field of heteroatom chemistry.