基于吩噻嗪和喹唑啉酮的比例荧光探针快速检测氯离子及其应用

IF 1.4 4区化学 Q4 CHEMISTRY, INORGANIC & NUCLEAR

Phosphorus, Sulfur, and Silicon and the Related Elements Pub Date : 2024-09-02 DOI:10.1080/10426507.2024.2410864

Cheng-lu Zhang , Jing-hao Guo , Yang Zhang , Lu Zhang , Chang Liu , Shi-ru Nie

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引用次数: 0

摘要

合成了一种具有大共轭体系（吩噻嗪与喹唑啉酮偶联）的新型荧光探针（BPQ-1）。BPQ-1在10 s内对ClO -表现出显著的比例荧光响应，具有大斯托克斯位移（168 nm）、高灵敏度（LOD = 16.7 nm）和优良的选择性。在待检测的分析物中，只有在BPQ-1中加入ClO−后，BPQ-1的荧光才会由亮黄色变为青色。通过密度泛函理论计算和质谱实验，给出了BPQ-1的荧光响应机理。此外，BPQ-1已成功地应用于实际水样中ClO -的检测，并制备了检测不同浓度ClO -的试纸条。特别是，该探针已成功应用于活细胞中外源性ClO−的荧光成像。

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A ratiometric fluorescent probe based on phenothiazine and quinazolinone for rapid detection of ClO− and its application

A novel fluorescent probe (BPQ-1) with large conjugated system (phenothiazine was conjugated with quinazolinone) was synthesized. BPQ-1 showed a remarkable ratiometric fluorescence response to ClO⁻ within 10 s, and achieved large stokes shift (168 nm), high sensitivity (LOD = 16.7 nM) and excellent selectivity. Among the analytes to be detected, there is a significant change from bright yellow fluorescence to cyan fluorescence only when ClO⁻ is added to BPQ-1. Through density functional theory calculation and mass spectrometry experiments, the fluorescence response mechanisms of the BPQ-1 are given. In addition, BPQ-1 has been successfully applied to the detection of ClO⁻ in real water samples and test strips for detecting ClO⁻ with different concentrations have been prepared. In particular, the probe has been successfully applied to the fluorescence imaging of exogenous ClO⁻ in living cells.

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来源期刊

Phosphorus, Sulfur, and Silicon and the Related Elements 化学-无机化学与核化学

CiteScore

2.60

自引率

7.70%

发文量

103

审稿时长

2.1 months

期刊介绍： Phosphorus, Sulfur, and Silicon and the Related Elements is a monthly publication intended to disseminate current trends and novel methods to those working in the broad and interdisciplinary field of heteroatom chemistry.