槲皮素对乳腺癌细胞系microrna表达的影响：系统综述

IF 0.5 Q4 GENETICS & HEREDITY

Human Gene Pub Date : 2025-02-01 DOI:10.1016/j.humgen.2025.201379

Niloofar Sharbati , Mohammad Hossein Dehghan , Malihe Safavi , Malihe Farid , Naghmeh Zhalehjoo

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引用次数: 0

摘要

虽然标准的治疗方式显著改善了乳腺癌（BC）患者的治疗，但BC是世界范围内癌症死亡的最常见的主要原因。有证据表明槲皮素可以通过调控microRNA （microRNA）的表达，抑制肿瘤细胞的信号转导，诱导癌细胞凋亡，抑制肿瘤细胞的增殖、侵袭和转移。因此，本研究旨在系统评估槲皮素对BC细胞系miRNA表达的影响。综合检索Scopus、Cochrane Library、PubMed、Web of Science等电子数据库，检索关键词为“MicroRNA”、“Quercetin”、“Normal tissue”、“Breast cancer”、“Cell line”、“Apoptosis”、“Survival”、“Prognosis”、“Up-regulation”、“Down-regulation”、“Proliferation”、“Overexpression”、“Lower expression”，检索到2023年8月前发表的相关文章。研究槲皮素对BC细胞系的影响。提取miRNA表达和细胞存活数据。最初，检索到6753项研究，其中14项符合纳入标准。因此，有2项研究被纳入最终评价。2项研究发现槲皮素可以通过上调MCF-7和MDA-MB-231细胞系中的miR-146a，下调MCF-7细胞中的miR-21来抑制BC细胞系的进展。我们的研究表明槲皮素对BC细胞株的抑制作用可以通过miRNA的表达来实现。

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The effects of Quercetin on microRNAs expression in the breast cancer cell lines: A systematic review

Although standard therapeutic modalities have significantly improved the treatment of patients with Breast Cancer (BC), BC is the most common leading cause of cancer mortality worldwide. Evidence indicates that Quercetin could inhibit signal transduction, induce cancer cell apoptosis, and suppress proliferation, invasion, and metastases of tumor cells via regulation of microRNA (miRNA) expression. Hence, this study was conducted to systematically assess the effect of Quercetin on miRNA expression in BC cell lines.

A comprehensive search of electronic databases including Scopus, Cochrane Library, PubMed, and Web of Science was conducted with keywords (i.e., “MicroRNA”,” Quercetin”, “Normal tissue”, “Breast cancer”, “Cell line”, “Apoptosis”, “Survival”, “Prognosis”, “Up-regulation”, “Down-regulation”, “Proliferation”, “Overexpression”, and “Lower expression”) to identify relative articles published until August 2023. Studies that investigated the effects of Quercetin on BC cell lines were included. Data regarding miRNA expression and cell survival were extracted.

Initially, 6753 studies were retrieved, of which 14 met inclusion criteria. Accordingly, 2 studies were included in the final assessment. The findings of 2 studies revealed that Quercetin could inhibit the progression of BC cell lines through up-regulation of the miR-146a in MCF-7 and MDA-MB-231 cell lines, and down-regulation of miR-21 in MCF-7 cells.

Our study showed that the inhibition role of Quercetin on BC cell line could be provided via miRNA expression.

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