卵巢储备参数的差异：年龄，雌激素水平和出生率

IF 3.5 2区医学 Q1 OBSTETRICS & GYNECOLOGY

Reproductive biomedicine online Pub Date : 2024-11-01 Epub Date: 2024-12-04 DOI:10.1016/j.rbmo.2024.104594

Duygu Kütük , İbrahim Orçun Olcay , Berkay Akçay , Çağri Öner , Ertuğrul Çolak

{"title":"卵巢储备参数的差异：年龄，雌激素水平和出生率","authors":"Duygu Kütük , İbrahim Orçun Olcay , Berkay Akçay , Çağri Öner , Ertuğrul Çolak","doi":"10.1016/j.rbmo.2024.104594","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><div>Reduced fertility is likely the result of low oocyte developmental competence and inadequate maternal environment to support pregnancy. The aim of IVF treatment is to obtain interpretable and improvable results on the effects of parameters affecting fertility on pregnancy. Clinical information including female age (22-46), E2 levels on the day of opu and pregnancy status of 200 patients who came to Bahçeci Umut IVF Center for treatment between 2022-2023 were analyzed retrospectively (2022/20-05).</div></div><div><h3>Materials and methods</h3><div>Patient groups were determined as Control(NR), Polycystic Ovary Syndrome(PCOS), Advanced(DOR-I)and Early Age(DOR-G) low ovarian reserve.</div></div><div><h3>Results</h3><div>E2 was higher in PCOS (3421,29 ± 1998,92 pg/ml) than NR (1540,39 ± 462,63 pg/ml), DOR-I (719,65 ± 303,02 pg/ml), or DOR-G (940,70 ± 339,49 pg/ml). DOR-I and DOR-G had similar E2 (p>0.05, Table 1). DOR-I (40.36±3.082) was significantly older than other groups (p>0.05,Figure 1).</div><div>NR (%16) had the highest pregnancy loss rates compared to PCOS (%10), DOR-G (%14) and DOR-I (%8). PCOS (%36) had higher live birth rates than NR(%24), DOR-G(%22) and DOR-I(%16). DOR-G (%4) had higher biochemical pregnancy than PCOS(% 0) and DOR-I(%2) groups. The percentage of embryo transfer cancellation was higher in DOR-I (%30) than NR(%6) PCOS(%10) and DOR-G(%0).</div></div><div><h3>Conclusions</h3><div>Only DOR-I is is older than the NR group. E2 seems correlated with the number of oocytes collected and in the formation of indication groups. It confirms research findings that aging can lead to oocyte anomalies and infertility.</div></div>","PeriodicalId":21134,"journal":{"name":"Reproductive biomedicine online","volume":"49 ","pages":"Article 104594"},"PeriodicalIF":3.5000,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"THE DIFFERENCES BETWEEN OVARIAN RESERVE PARAMETERS: AGE, ESTROGEN LEVEL AND BIRTH RATES\",\"authors\":\"Duygu Kütük , İbrahim Orçun Olcay , Berkay Akçay , Çağri Öner , Ertuğrul Çolak\",\"doi\":\"10.1016/j.rbmo.2024.104594\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><div>Reduced fertility is likely the result of low oocyte developmental competence and inadequate maternal environment to support pregnancy. The aim of IVF treatment is to obtain interpretable and improvable results on the effects of parameters affecting fertility on pregnancy. Clinical information including female age (22-46), E2 levels on the day of opu and pregnancy status of 200 patients who came to Bahçeci Umut IVF Center for treatment between 2022-2023 were analyzed retrospectively (2022/20-05).</div></div><div><h3>Materials and methods</h3><div>Patient groups were determined as Control(NR), Polycystic Ovary Syndrome(PCOS), Advanced(DOR-I)and Early Age(DOR-G) low ovarian reserve.</div></div><div><h3>Results</h3><div>E2 was higher in PCOS (3421,29 ± 1998,92 pg/ml) than NR (1540,39 ± 462,63 pg/ml), DOR-I (719,65 ± 303,02 pg/ml), or DOR-G (940,70 ± 339,49 pg/ml). DOR-I and DOR-G had similar E2 (p>0.05, Table 1). DOR-I (40.36±3.082) was significantly older than other groups (p>0.05,Figure 1).</div><div>NR (%16) had the highest pregnancy loss rates compared to PCOS (%10), DOR-G (%14) and DOR-I (%8). PCOS (%36) had higher live birth rates than NR(%24), DOR-G(%22) and DOR-I(%16). DOR-G (%4) had higher biochemical pregnancy than PCOS(% 0) and DOR-I(%2) groups. The percentage of embryo transfer cancellation was higher in DOR-I (%30) than NR(%6) PCOS(%10) and DOR-G(%0).</div></div><div><h3>Conclusions</h3><div>Only DOR-I is is older than the NR group. E2 seems correlated with the number of oocytes collected and in the formation of indication groups. It confirms research findings that aging can lead to oocyte anomalies and infertility.</div></div>\",\"PeriodicalId\":21134,\"journal\":{\"name\":\"Reproductive biomedicine online\",\"volume\":\"49 \",\"pages\":\"Article 104594\"},\"PeriodicalIF\":3.5000,\"publicationDate\":\"2024-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Reproductive biomedicine online\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1472648324007831\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/12/4 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"OBSTETRICS & GYNECOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Reproductive biomedicine online","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1472648324007831","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/12/4 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

目的卵细胞发育能力低下和母体妊娠环境不足可能是导致生育能力下降的原因。体外受精治疗的目的是获得可解释和可改进的结果，影响生育能力的参数对妊娠的影响。回顾性分析2022-2023年间来baheci Umut IVF中心治疗的200例患者的临床资料，包括女性年龄（22-46岁）、分娩当日E2水平及妊娠情况。材料与方法将患者分为对照组（NR）、多囊卵巢综合征（PCOS）、晚期（dor - 1）和早期（DOR-G）低卵巢储备组。结果2在PCOS中的含量（3421、29±1998、92 pg/ml）高于NR（1540、39±462、63 pg/ml）、dor - 1（719、65±303、02 pg/ml）和DOR-G（940、70±339、49 pg/ml）。dor - 1与DOR-G E2相似（p>0.05，表1），dor - 1（40.36±3.082）明显大于其他组（p>0.05，图1），nr（%16）的妊娠失败率高于PCOS（%10）、DOR-G（%14）和dor - 1（%8）。PCOS（%36）的活产率高于NR（%24）、DOR-G（%22）和dor - 1（%16）。DOR-G（%4）组生化妊娠高于PCOS（% 0）组和dor - 1（%2）组。dor - 1的胚胎移植取消率（%30）高于NR（%6）、PCOS（%10）和DOR-G（%0）。结论只有dor - 1组比NR组年龄大。E2似乎与收集的卵母细胞数量和适应证组的形成有关。它证实了研究发现，衰老会导致卵母细胞异常和不孕。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

THE DIFFERENCES BETWEEN OVARIAN RESERVE PARAMETERS: AGE, ESTROGEN LEVEL AND BIRTH RATES

Objective

Reduced fertility is likely the result of low oocyte developmental competence and inadequate maternal environment to support pregnancy. The aim of IVF treatment is to obtain interpretable and improvable results on the effects of parameters affecting fertility on pregnancy. Clinical information including female age (22-46), E2 levels on the day of opu and pregnancy status of 200 patients who came to Bahçeci Umut IVF Center for treatment between 2022-2023 were analyzed retrospectively (2022/20-05).

Materials and methods

Patient groups were determined as Control(NR), Polycystic Ovary Syndrome(PCOS), Advanced(DOR-I)and Early Age(DOR-G) low ovarian reserve.

Results

E2 was higher in PCOS (3421,29 ± 1998,92 pg/ml) than NR (1540,39 ± 462,63 pg/ml), DOR-I (719,65 ± 303,02 pg/ml), or DOR-G (940,70 ± 339,49 pg/ml). DOR-I and DOR-G had similar E2 (p>0.05, Table 1). DOR-I (40.36±3.082) was significantly older than other groups (p>0.05,Figure 1).

NR (%16) had the highest pregnancy loss rates compared to PCOS (%10), DOR-G (%14) and DOR-I (%8). PCOS (%36) had higher live birth rates than NR(%24), DOR-G(%22) and DOR-I(%16). DOR-G (%4) had higher biochemical pregnancy than PCOS(% 0) and DOR-I(%2) groups. The percentage of embryo transfer cancellation was higher in DOR-I (%30) than NR(%6) PCOS(%10) and DOR-G(%0).

Conclusions

Only DOR-I is is older than the NR group. E2 seems correlated with the number of oocytes collected and in the formation of indication groups. It confirms research findings that aging can lead to oocyte anomalies and infertility.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Reproductive biomedicine online 医学-妇产科学

CiteScore

7.20

自引率

7.50%

发文量

391

审稿时长

50 days

期刊介绍： Reproductive BioMedicine Online covers the formation, growth and differentiation of the human embryo. It is intended to bring to public attention new research on biological and clinical research on human reproduction and the human embryo including relevant studies on animals. It is published by a group of scientists and clinicians working in these fields of study. Its audience comprises researchers, clinicians, practitioners, academics and patients. Context: The period of human embryonic growth covered is between the formation of the primordial germ cells in the fetus until mid-pregnancy. High quality research on lower animals is included if it helps to clarify the human situation. Studies progressing to birth and later are published if they have a direct bearing on events in the earlier stages of pregnancy.