一种通过荧光光谱和机器学习快速检测苯二氮卓类药物和合成大麻素的装置

A. Power, M. Gardner, C. Pudney
{"title":"一种通过荧光光谱和机器学习快速检测苯二氮卓类药物和合成大麻素的装置","authors":"A. Power,&nbsp;M. Gardner,&nbsp;C. Pudney","doi":"10.1016/j.etdah.2023.100110","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><div>Drug abuse is a worsening societal issue across the globe. In the UK, the abuse of Benzodiazepines and Synthetic Cannabinoids is particularly prevalent, especially in healthcare and custodial settings, and there is currently no solution to quickly detect these substances for harm reduction.</div></div><div><h3>Methods</h3><div>We are developing a portable and rapid device that utilizes Fluorescence Spectroscopy and Machine Learning to detect Benzodiazepines and Synthetic Cannabinoids in a variety of media, including saliva. The device will be able to distinguish between variants of a given drug to provide an informative output to the end user.</div></div><div><h3>Results</h3><div>Development of the first prototype of the device is nearing completion, and lab data has been collected for training the device's drug-detecting predictive model. Current experiments with established supervised-learning algorithms show favourable results in distinguishing Synthetic Cannabinoids. Trials of the device in UK drug hotspots are imminent and will result in a significant data collection of the scans performed and the predictions that the model made per scan. This will provide us with an unprecedented insight into the pervasiveness of illegal drug use in the UK and drive improvements for future iterations of the device.</div></div><div><h3>Conclusions</h3><div>We feel that this is a crucial and promising technology for harm reduction to stem the flow of drugs to the most vulnerable in society.</div></div>","PeriodicalId":72899,"journal":{"name":"Emerging trends in drugs, addictions, and health","volume":"4 ","pages":"Article 100110"},"PeriodicalIF":0.0000,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A Device for the Rapid Detection of Benzodiazepines and Synthetic Cannabinoids via Fluorescence Spectroscopy and Machine Learning\",\"authors\":\"A. Power,&nbsp;M. Gardner,&nbsp;C. Pudney\",\"doi\":\"10.1016/j.etdah.2023.100110\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Introduction</h3><div>Drug abuse is a worsening societal issue across the globe. In the UK, the abuse of Benzodiazepines and Synthetic Cannabinoids is particularly prevalent, especially in healthcare and custodial settings, and there is currently no solution to quickly detect these substances for harm reduction.</div></div><div><h3>Methods</h3><div>We are developing a portable and rapid device that utilizes Fluorescence Spectroscopy and Machine Learning to detect Benzodiazepines and Synthetic Cannabinoids in a variety of media, including saliva. The device will be able to distinguish between variants of a given drug to provide an informative output to the end user.</div></div><div><h3>Results</h3><div>Development of the first prototype of the device is nearing completion, and lab data has been collected for training the device's drug-detecting predictive model. Current experiments with established supervised-learning algorithms show favourable results in distinguishing Synthetic Cannabinoids. Trials of the device in UK drug hotspots are imminent and will result in a significant data collection of the scans performed and the predictions that the model made per scan. This will provide us with an unprecedented insight into the pervasiveness of illegal drug use in the UK and drive improvements for future iterations of the device.</div></div><div><h3>Conclusions</h3><div>We feel that this is a crucial and promising technology for harm reduction to stem the flow of drugs to the most vulnerable in society.</div></div>\",\"PeriodicalId\":72899,\"journal\":{\"name\":\"Emerging trends in drugs, addictions, and health\",\"volume\":\"4 \",\"pages\":\"Article 100110\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Emerging trends in drugs, addictions, and health\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2667118223000612\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Emerging trends in drugs, addictions, and health","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2667118223000612","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

药物滥用在全球范围内是一个日益恶化的社会问题。在英国,苯二氮卓类药物和合成大麻素的滥用尤其普遍,特别是在医疗保健和监禁环境中,目前没有快速检测这些物质以减少危害的解决方案。方法我们正在开发一种便携式快速设备,利用荧光光谱和机器学习来检测包括唾液在内的各种介质中的苯二氮卓类药物和合成大麻素。该设备将能够区分给定药物的变体,从而为最终用户提供信息输出。该设备的第一个原型的开发接近完成,并且已经收集了用于训练该设备的药物检测预测模型的实验室数据。目前的实验与建立监督学习算法显示有利的结果在区分合成大麻素。该设备即将在英国的药物热点地区进行试验,并将产生重要的扫描数据收集和模型每次扫描的预测。这将使我们对英国非法药物使用的普遍性有一个前所未有的了解,并推动该设备未来迭代的改进。结论我们认为,这是一项至关重要且有前途的技术,可以减少危害,阻止毒品流向社会中最脆弱的群体。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Device for the Rapid Detection of Benzodiazepines and Synthetic Cannabinoids via Fluorescence Spectroscopy and Machine Learning

Introduction

Drug abuse is a worsening societal issue across the globe. In the UK, the abuse of Benzodiazepines and Synthetic Cannabinoids is particularly prevalent, especially in healthcare and custodial settings, and there is currently no solution to quickly detect these substances for harm reduction.

Methods

We are developing a portable and rapid device that utilizes Fluorescence Spectroscopy and Machine Learning to detect Benzodiazepines and Synthetic Cannabinoids in a variety of media, including saliva. The device will be able to distinguish between variants of a given drug to provide an informative output to the end user.

Results

Development of the first prototype of the device is nearing completion, and lab data has been collected for training the device's drug-detecting predictive model. Current experiments with established supervised-learning algorithms show favourable results in distinguishing Synthetic Cannabinoids. Trials of the device in UK drug hotspots are imminent and will result in a significant data collection of the scans performed and the predictions that the model made per scan. This will provide us with an unprecedented insight into the pervasiveness of illegal drug use in the UK and drive improvements for future iterations of the device.

Conclusions

We feel that this is a crucial and promising technology for harm reduction to stem the flow of drugs to the most vulnerable in society.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Emerging trends in drugs, addictions, and health
Emerging trends in drugs, addictions, and health Pharmacology, Psychiatry and Mental Health, Forensic Medicine, Drug Discovery, Pharmacology, Toxicology and Pharmaceutics (General)
CiteScore
2.40
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信