Marcos Vinícius Melo de Oliveira MD, PhD , Alexandre Malta Brandão MD, PhD , Gina Camillo Rocha Silvestre BS , Alexandre Queiroz Silva BS , Michele Alberto Marques BS , Marcia Martins Reis PhD , Maria de Lourdes Higuchi MD, PhD , Erasmo Simão da Silva MD, PhD
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Biomechanical testing assessed arterial wall mechanical strength and elasticity, and histological and immunohistochemical analyses examined tissue composition and inflammatory markers.</div></div><div><h3>Results</h3><div>PAA wall fragments demonstrate higher failure strain energy (13.36 N/m<sup>2</sup> vs 9.95 N/m<sup>2</sup>; <em>P</em> = .023), a measure of mechanical strength. Regarding immunohistochemical markers, AAA exhibited more B lymphocyte cells in the adventitia (CD20 1475.50 vs 320; <em>P</em> = .003) compared with PAA. Additionally, AAA demonstrated more adipogenic differentiation in the adventitia (PPARgamma 4854.50 vs 778; <em>P</em> = .009), whereas PAA showed more adipogenic differentiation in the intima (KLF5 283.50 vs 77.50; <em>P</em> = .039).</div></div><div><h3>Conclusions</h3><div>PAA wall fragments demonstrate greater mechanical strength compared with AAA wall fragments. In contrast, AAA walls contain a greater number of B lymphocytes within the adventitia compared with PAA walls. Adipogenic differentiation is more pronounced in the adventitia of AAA than in PAA, whereas in PAA, it is more prominent in the intima compared with AAA.</div></div><div><h3>Clinical Relevance</h3><div>The clinical significance of this study lies in its potential to enhance our understanding of the distinct pathophysiological mechanisms underlying abdominal aortic aneurysms, which is often associated with rupture, and popliteal artery aneurysms, which are more prone to thrombosis and distal embolization. By comprehensively comparing the biomechanical, histological, and immunohistochemical aspects of these two aneurysm types, the study aims to illuminate the factors contributing to their differing clinical presentations and outcomes.</div></div>","PeriodicalId":74035,"journal":{"name":"JVS-vascular science","volume":"6 ","pages":"Article 100279"},"PeriodicalIF":0.0000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Comparative analysis between abdominal aortic aneurysm and popliteal artery aneurysm\",\"authors\":\"Marcos Vinícius Melo de Oliveira MD, PhD , Alexandre Malta Brandão MD, PhD , Gina Camillo Rocha Silvestre BS , Alexandre Queiroz Silva BS , Michele Alberto Marques BS , Marcia Martins Reis PhD , Maria de Lourdes Higuchi MD, PhD , Erasmo Simão da Silva MD, PhD\",\"doi\":\"10.1016/j.jvssci.2024.100279\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><div>Infrarenal abdominal aortic aneurysm (AAA) and popliteal artery aneurysm (PAA) are localized arterial dilatations with distinct clinical outcomes. This study aimed to comprehensively compare these two types of aneurysms' biomechanical, histological, and immunohistochemical characteristics.</div></div><div><h3>Methods</h3><div>This study included 180 patients with AAA and 18 with PAA. Medical history and imaging data were collected. Biomechanical testing assessed arterial wall mechanical strength and elasticity, and histological and immunohistochemical analyses examined tissue composition and inflammatory markers.</div></div><div><h3>Results</h3><div>PAA wall fragments demonstrate higher failure strain energy (13.36 N/m<sup>2</sup> vs 9.95 N/m<sup>2</sup>; <em>P</em> = .023), a measure of mechanical strength. Regarding immunohistochemical markers, AAA exhibited more B lymphocyte cells in the adventitia (CD20 1475.50 vs 320; <em>P</em> = .003) compared with PAA. Additionally, AAA demonstrated more adipogenic differentiation in the adventitia (PPARgamma 4854.50 vs 778; <em>P</em> = .009), whereas PAA showed more adipogenic differentiation in the intima (KLF5 283.50 vs 77.50; <em>P</em> = .039).</div></div><div><h3>Conclusions</h3><div>PAA wall fragments demonstrate greater mechanical strength compared with AAA wall fragments. In contrast, AAA walls contain a greater number of B lymphocytes within the adventitia compared with PAA walls. Adipogenic differentiation is more pronounced in the adventitia of AAA than in PAA, whereas in PAA, it is more prominent in the intima compared with AAA.</div></div><div><h3>Clinical Relevance</h3><div>The clinical significance of this study lies in its potential to enhance our understanding of the distinct pathophysiological mechanisms underlying abdominal aortic aneurysms, which is often associated with rupture, and popliteal artery aneurysms, which are more prone to thrombosis and distal embolization. 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引用次数: 0
摘要
目的：肾下腹主动脉瘤（AAA）和腘动脉动脉瘤（PAA）是两种具有不同临床结局的局限性动脉扩张。本研究旨在全面比较这两种动脉瘤的生物力学、组织学和免疫组织化学特征。方法本研究纳入AAA患者180例，PAA患者18例。收集病史和影像学资料。生物力学测试评估了动脉壁的机械强度和弹性，组织学和免疫组织化学分析检查了组织成分和炎症标志物。结果spaa壁片具有较高的破坏应变能（13.36 N/m2 vs 9.95 N/m2）；P = .023)，是机械强度的量度。在免疫组织化学标志物方面，AAA在外膜中显示更多的B淋巴细胞(CD20 1475.50 vs 320；P = .003)。此外，AAA表现出更多的外膜脂肪分化(PPARgamma 4854.50 vs 778；P = 0.009)，而PAA在内膜中显示更多的脂肪分化(KLF5 283.50 vs 77.50；p = .039)。结论spaa壁片比AAA壁片具有更高的机械强度。相反，与PAA壁相比，AAA壁在外膜内含有更多的B淋巴细胞。AAA的外膜比PAA的脂肪分化更明显，而PAA的内膜比AAA的脂肪分化更突出。临床意义本研究的临床意义在于，它有可能加深我们对腹主动脉瘤不同的病理生理机制的理解，腹主动脉瘤常伴有破裂，腘动脉动脉瘤更容易形成血栓和远端栓塞。通过全面比较这两种动脉瘤类型的生物力学、组织学和免疫组织化学方面，本研究旨在阐明导致其不同临床表现和结果的因素。
Comparative analysis between abdominal aortic aneurysm and popliteal artery aneurysm
Objective
Infrarenal abdominal aortic aneurysm (AAA) and popliteal artery aneurysm (PAA) are localized arterial dilatations with distinct clinical outcomes. This study aimed to comprehensively compare these two types of aneurysms' biomechanical, histological, and immunohistochemical characteristics.
Methods
This study included 180 patients with AAA and 18 with PAA. Medical history and imaging data were collected. Biomechanical testing assessed arterial wall mechanical strength and elasticity, and histological and immunohistochemical analyses examined tissue composition and inflammatory markers.
Results
PAA wall fragments demonstrate higher failure strain energy (13.36 N/m2 vs 9.95 N/m2; P = .023), a measure of mechanical strength. Regarding immunohistochemical markers, AAA exhibited more B lymphocyte cells in the adventitia (CD20 1475.50 vs 320; P = .003) compared with PAA. Additionally, AAA demonstrated more adipogenic differentiation in the adventitia (PPARgamma 4854.50 vs 778; P = .009), whereas PAA showed more adipogenic differentiation in the intima (KLF5 283.50 vs 77.50; P = .039).
Conclusions
PAA wall fragments demonstrate greater mechanical strength compared with AAA wall fragments. In contrast, AAA walls contain a greater number of B lymphocytes within the adventitia compared with PAA walls. Adipogenic differentiation is more pronounced in the adventitia of AAA than in PAA, whereas in PAA, it is more prominent in the intima compared with AAA.
Clinical Relevance
The clinical significance of this study lies in its potential to enhance our understanding of the distinct pathophysiological mechanisms underlying abdominal aortic aneurysms, which is often associated with rupture, and popliteal artery aneurysms, which are more prone to thrombosis and distal embolization. By comprehensively comparing the biomechanical, histological, and immunohistochemical aspects of these two aneurysm types, the study aims to illuminate the factors contributing to their differing clinical presentations and outcomes.
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