静脉利多卡因与静脉氯胺酮在纤维肌痛患者疼痛管理中的潜在作用

IF 1 Q2 Nursing

Perioperative Care and Operating Room Management Pub Date : 2025-01-06 DOI:10.1016/j.pcorm.2025.100462

Maha Sadek El Derh , Sherif Essam Shabaan , Sally Saber AbdelAziz , Reham M. Hashim

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引用次数: 0

摘要

纤维肌痛综合征（FMS）是一种以慢性疼痛为特征的疾病，与身体功能受损和整体生活质量（QOL）相关。疼痛可以通过静脉注射利多卡因来控制，利多卡因被认为是一种表面麻醉剂。此外，氯胺酮被用作一种有效的麻醉剂，减少突触可塑性的诱导和慢性疼痛状态的维持。本研究旨在评估静脉注射利多卡因与静脉注射氯胺酮在FM患者疼痛管理和生活质量改善方面的疗效。方法75例患者随机分为3组，A组给予利多卡因5 mg/Kg， B组给予硫酸氯胺酮0.5 mg/Kg， C组给予生理盐水安慰剂。该手术每周进行一次，持续3周。结果在疼痛感知方面，a、B组VAS评分明显降低，两组间无差异，c组无变化。对纤维肌痛影响问卷（FIQ）的变化进行分析，发现各组健康评分的精神部分显著降低，而健康评分的身体和整体部分仅利多卡因氯胺酮组显著降低，安慰剂组无显著变化。术后4周，健康相关生活质量（HrQOL） SF-12问卷评估a、B组患者总体生活质量显著提高。结论静脉注射利多卡因和氯胺酮不仅能有效缓解FM患者的疼痛，还能改善患者的身体功能和生活质量。

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Potential role of intravenous lidocaine versus intravenous ketamine for pain management in fibromyalgia patients

Introduction

Fibromyalgia syndrome (FMS) is a disease characterized by chronic, pain associated with impaired physical function and overall quality of life (QOL). Pain can be controlled by IV lidocaine which is considered a topical anesthetic drug. Also, ketamine is used as a potent anesthetic agent reducing the induction of synaptic plasticity and maintenance of chronic pain states.

This study aimed

to assess the efficacy of intravenous (IV) lidocaine versus IV ketamine in pain management and improvement in the QOL in FM patients.

Patients &methods

75 patients were divided equally into 3 groups in which group A received 5 mg/Kg lidocaine, group B received 0.5 mg/Kg ketamine sulphate and group C received a placebo of normal saline. This procedure was done weekly for 3 weeks.

Result

As regards pain perception using VAS group A&B showed a marked reduction in VAS with no difference between them, with no change in group C. Changes in the fibromyalgia impact questionnaire (FIQ) were analyzed and showed the mental part of the health score decreased significantly in all groups while the physical and overall parts of the health score decreased significantly only in the lidocaine and ketamine group and non-significantly changed in the placebo group. Overall QOL significantly improved in groups A&B assessed by Health-related quality of life (HrQOL) SF-12 questionnaire 4 weeks post-procedure.

Conclusion

IV lidocaine and ketamine are efficient not only in pain relief among patients with FM but also in improving physical function and QOL.

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来源期刊

Perioperative Care and Operating Room Management Nursing-Medical and Surgical Nursing

CiteScore

1.30

自引率

0.00%

发文量

审稿时长

56 days

期刊介绍： The objective of this new online journal is to serve as a multidisciplinary, peer-reviewed source of information related to the administrative, economic, operational, safety, and quality aspects of the ambulatory and in-patient operating room and interventional procedural processes. The journal will provide high-quality information and research findings on operational and system-based approaches to ensure safe, coordinated, and high-value periprocedural care. With the current focus on value in health care it is essential that there is a venue for researchers to publish articles on quality improvement process initiatives, process flow modeling, information management, efficient design, cost improvement, use of novel technologies, and management.