María José Durán-Maseda , María Vidal-Millares , Vicente Álvarez Pérez
{"title":"母亲流感对精神分裂症的影响。1999 - 2007年在西班牙加利西亚进行的流行病学研究","authors":"María José Durán-Maseda , María Vidal-Millares , Vicente Álvarez Pérez","doi":"10.1016/j.psiq.2024.100545","DOIUrl":null,"url":null,"abstract":"<div><div>The etiology of schizophrenia remains unknown. From the late eighties onwards, a range of theories has been put forward identifying various possible risk factors. One of these was the flu infection (Influenza A virus) during pregnancy, which argues, as a result of an increased incidence being detected in those born in the winter and spring months, that it can affect fetal neurodevelopment. However, the findings which correlate the two are contradictory.</div><div>The aim of this study is to link the fluctuations between the distribution of the dates of birth of patients diagnosed with schizophrenia and the distribution of the incidence dates of flu in the general population.</div><div>Between 1999 and 2007, a total of 5,911 new diagnoses of schizophrenia were recorded in Galicia, an autonomous region of Spain with a total population of 2,699,499. Furthermore, we have the week-by-week incidence of flu in the general population from 1964 to 2011. On average, the incidence of flu is concentrated in the final 15 weeks and the first 15 weeks of each year, with a higher number of cases registered in the years 1973, 1975 and 2000.</div><div>To corroborate the causal hypothesis, the dates of birth of the patients diagnosed with schizophrenia were offset in order to determine the approximate week of conception. Subsequently, this was compared against the 48-weekly distribution of flu, one for each year recorded, by means of the 2 tests. The result of this test rejects the possible causality between the incidence of flu in the mother and the development of schizophrenia in her child.</div></div>","PeriodicalId":39337,"journal":{"name":"Psiquiatria Biologica","volume":"32 2","pages":"Article 100545"},"PeriodicalIF":0.0000,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Influencia de la gripe materna en la esquizofrenia. Estudio epidemiológico en Galicia (España), de 1999 a 2007\",\"authors\":\"María José Durán-Maseda , María Vidal-Millares , Vicente Álvarez Pérez\",\"doi\":\"10.1016/j.psiq.2024.100545\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>The etiology of schizophrenia remains unknown. From the late eighties onwards, a range of theories has been put forward identifying various possible risk factors. One of these was the flu infection (Influenza A virus) during pregnancy, which argues, as a result of an increased incidence being detected in those born in the winter and spring months, that it can affect fetal neurodevelopment. However, the findings which correlate the two are contradictory.</div><div>The aim of this study is to link the fluctuations between the distribution of the dates of birth of patients diagnosed with schizophrenia and the distribution of the incidence dates of flu in the general population.</div><div>Between 1999 and 2007, a total of 5,911 new diagnoses of schizophrenia were recorded in Galicia, an autonomous region of Spain with a total population of 2,699,499. Furthermore, we have the week-by-week incidence of flu in the general population from 1964 to 2011. On average, the incidence of flu is concentrated in the final 15 weeks and the first 15 weeks of each year, with a higher number of cases registered in the years 1973, 1975 and 2000.</div><div>To corroborate the causal hypothesis, the dates of birth of the patients diagnosed with schizophrenia were offset in order to determine the approximate week of conception. Subsequently, this was compared against the 48-weekly distribution of flu, one for each year recorded, by means of the 2 tests. The result of this test rejects the possible causality between the incidence of flu in the mother and the development of schizophrenia in her child.</div></div>\",\"PeriodicalId\":39337,\"journal\":{\"name\":\"Psiquiatria Biologica\",\"volume\":\"32 2\",\"pages\":\"Article 100545\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-11-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Psiquiatria Biologica\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1134593424001052\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Psiquiatria Biologica","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1134593424001052","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
Influencia de la gripe materna en la esquizofrenia. Estudio epidemiológico en Galicia (España), de 1999 a 2007
The etiology of schizophrenia remains unknown. From the late eighties onwards, a range of theories has been put forward identifying various possible risk factors. One of these was the flu infection (Influenza A virus) during pregnancy, which argues, as a result of an increased incidence being detected in those born in the winter and spring months, that it can affect fetal neurodevelopment. However, the findings which correlate the two are contradictory.
The aim of this study is to link the fluctuations between the distribution of the dates of birth of patients diagnosed with schizophrenia and the distribution of the incidence dates of flu in the general population.
Between 1999 and 2007, a total of 5,911 new diagnoses of schizophrenia were recorded in Galicia, an autonomous region of Spain with a total population of 2,699,499. Furthermore, we have the week-by-week incidence of flu in the general population from 1964 to 2011. On average, the incidence of flu is concentrated in the final 15 weeks and the first 15 weeks of each year, with a higher number of cases registered in the years 1973, 1975 and 2000.
To corroborate the causal hypothesis, the dates of birth of the patients diagnosed with schizophrenia were offset in order to determine the approximate week of conception. Subsequently, this was compared against the 48-weekly distribution of flu, one for each year recorded, by means of the 2 tests. The result of this test rejects the possible causality between the incidence of flu in the mother and the development of schizophrenia in her child.
期刊介绍:
Es la Publicación Oficial de la Sociedad Española de Psiquiatría Biológica. Los recientes avances en el conocimiento de la bioquímica y de la fisiología cerebrales y el progreso en general en el campo de las neurociencias han abierto el camino al desarrollo de la psiquiatría biológica, fundada sobre bases anatomofisiológicas, más sólidas y científicas que la psiquiatría tradicional.