母亲流感对精神分裂症的影响。1999 - 2007年在西班牙加利西亚进行的流行病学研究

Q4 Medicine
María José Durán-Maseda , María Vidal-Millares , Vicente Álvarez Pérez
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引用次数: 0

摘要

精神分裂症的病因尚不清楚。从八十年代末开始,人们提出了一系列理论,确定了各种可能的风险因素。其中之一是怀孕期间的流感感染(甲型流感病毒),该研究认为,由于在冬季和春季出生的婴儿中检测到的发病率增加,它会影响胎儿的神经发育。然而,将两者联系起来的研究结果是相互矛盾的。这项研究的目的是将诊断为精神分裂症患者的出生日期分布与普通人群中流感发病日期分布之间的波动联系起来。1999年至2007年间,西班牙加利西亚自治区共有5,911例新诊断的精神分裂症病例,加利西亚自治区总人口为2,699,499人。此外,从1964年到2011年,我们有每周流感在普通人群中的发病率。平均而言,流感的发病率集中在每年的最后15个 周和前15个 周,1973年、1975年和2000年登记的病例数量较多。为了证实因果假设,被诊断为精神分裂症的患者的出生日期被抵消,以确定大约的受孕周。随后,通过这两种测试,将这些数据与流感的48周分布(每年记录一次)进行比较。这个测试的结果否定了母亲患流感和孩子患精神分裂症之间可能存在的因果关系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Influencia de la gripe materna en la esquizofrenia. Estudio epidemiológico en Galicia (España), de 1999 a 2007
The etiology of schizophrenia remains unknown. From the late eighties onwards, a range of theories has been put forward identifying various possible risk factors. One of these was the flu infection (Influenza A virus) during pregnancy, which argues, as a result of an increased incidence being detected in those born in the winter and spring months, that it can affect fetal neurodevelopment. However, the findings which correlate the two are contradictory.
The aim of this study is to link the fluctuations between the distribution of the dates of birth of patients diagnosed with schizophrenia and the distribution of the incidence dates of flu in the general population.
Between 1999 and 2007, a total of 5,911 new diagnoses of schizophrenia were recorded in Galicia, an autonomous region of Spain with a total population of 2,699,499. Furthermore, we have the week-by-week incidence of flu in the general population from 1964 to 2011. On average, the incidence of flu is concentrated in the final 15 weeks and the first 15 weeks of each year, with a higher number of cases registered in the years 1973, 1975 and 2000.
To corroborate the causal hypothesis, the dates of birth of the patients diagnosed with schizophrenia were offset in order to determine the approximate week of conception. Subsequently, this was compared against the 48-weekly distribution of flu, one for each year recorded, by means of the 2 tests. The result of this test rejects the possible causality between the incidence of flu in the mother and the development of schizophrenia in her child.
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来源期刊
Psiquiatria Biologica
Psiquiatria Biologica Medicine-Psychiatry and Mental Health
CiteScore
0.40
自引率
0.00%
发文量
13
期刊介绍: Es la Publicación Oficial de la Sociedad Española de Psiquiatría Biológica. Los recientes avances en el conocimiento de la bioquímica y de la fisiología cerebrales y el progreso en general en el campo de las neurociencias han abierto el camino al desarrollo de la psiquiatría biológica, fundada sobre bases anatomofisiológicas, más sólidas y científicas que la psiquiatría tradicional.
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