斯皮兹黑色素细胞瘤vs黑色素瘤：一个涉及分子检测的案例

Diagnostic Histopathology Pub Date : 2025-02-01 DOI:10.1016/j.mpdhp.2024.11.008

Harriet Hunter, Jonathan Potts, Paul Craig

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引用次数: 0

摘要

本病例为黑色素细胞病变，经过分子检测，最终被归类为spitzoid melanoma。鉴别诊断为Spitz黑色素细胞瘤（非典型Spitz肿瘤）和Spitz样黑色素瘤。这是一个主观和模糊的病理领域，其中使用分子检测可以提供有用的诊断信息。在这个病例中，BRAF V600E突变和缺乏激酶融合导致了Spitz黑色素瘤的诊断，而不是Spitz家族的真正成员。

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Spitz melanocytoma vs melanoma: a case involving the use of molecular testing

This case is of a melanocytic lesion that was eventually classified as a spitzoid melanoma, after molecular testing. The differential diagnosis was between a Spitz melanocytoma (Atypical Spitz tumour) and a spitzoid melanoma. This is a subjective and ambiguous area of pathology, where the use of molecular testing can provide useful diagnostic information. In this case, a BRAF V600E mutation, and lack of kinase fusions, led to the diagnosis of a spitzoid melanoma, rather than a true member of the Spitz family.

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来源期刊

Diagnostic Histopathology Medicine-Pathology and Forensic Medicine

CiteScore

1.30

自引率

0.00%

发文量

期刊介绍： This monthly review journal aims to provide the practising diagnostic pathologist and trainee pathologist with up-to-date reviews on histopathology and cytology and related technical advances. Each issue contains invited articles on a variety of topics from experts in the field and includes a mini-symposium exploring one subject in greater depth. Articles consist of system-based, disease-based reviews and advances in technology. They update the readers on day-to-day diagnostic work and keep them informed of important new developments. An additional feature is the short section devoted to hypotheses; these have been refereed. There is also a correspondence section.