血清生长分化因子15与白细胞端粒长度呈负相关

IF 4 3区医学 Q1 GERIATRICS & GERONTOLOGY

Journal of Nutrition Health & Aging Pub Date : 2025-02-03 DOI:10.1016/j.jnha.2025.100493

Jie Yu, Yiwen Liu, Huabing Zhang, Fan Ping, Wei Li, Lingling Xu, Yuxiu Li

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引用次数: 0

摘要

端粒长度（TL）和线粒体DNA拷贝数（mtDNAcn）是衰老的经典生物标志物。近年来，生长分化因子15（growth differentiation factor 15, GDF15）作为衰老过程中的重要组成部分引起了人们的广泛关注。方法研究GDF15与端粒长度、mtDNAcn的关系。这是2014年至2021年在北京市昌平区进行的纵向队列研究的横断面分析。测定802例受试者的血清GDF15、白细胞端粒长度（LTL）和mtDNAcn。实时荧光定量PCR法测定LTL和mtDNAcn。采用多元线性回归和限制三次样条图进行统计分析。结果GDF15较高的受试者年龄较大，腰围较大，收缩压和糖化血红蛋白（HbA1c）较高，LTL较短，mtDNAcn较少。在相关分析中，GDF15与年龄呈正相关，LTL、mtDNAcn与年龄负相关。校正混杂因素后，GDF15与LTL呈负相关（β = - 0.120, 95%CI [- 0.197, - 0.042], p = 0.003），呈线性相关（非线性的p = 0.645），而GDF15与mtDNAcn呈负相关，无显著性。在分层分析中，GDF15和LTL之间的负相关在女性、超重个体或糖耐量异常（AGT）的受试者中更为突出，但在年轻人和老年人中也观察到类似的结果。本研究发现GDF - 15与LTL呈线性负相关，在女性、超重或AGT受试者中更为明显。这些结果支持GDF15可能是一种可靠的衰老生物标志物。

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Serum Growth Differentiation Factor 15 is Negatively Associated with Leukocyte Telomere Length

Background

Telomere length(TL)and mitochondrial DNA copy number(mtDNAcn) are classic biomarker of aging. Recently, growth differentiation factor 15(GDF15) has attracted considerable attention as a vital component in the aging process.

Methods

The present study aimed to study the relationship between GDF15 and telomere length and mtDNAcn.This was a cross-sectional analysis nested in a longitudinal cohort study conducted in Changping District, Beijing, from 2014 to 2021. Serum GDF15,leukocyte lelomere length(LTL) and mtDNAcn were determined in 802 subjects.LTL and mtDNAcn was quantified by real-time PCR assay. Multivariate linear regression and restricted cubic spline diagram were used for statistical analysis.

Results

Subjects with higher GDF15 were older,had larger waist circumference, higher systolic blood pressure and glycated hemoglobin A1c (HbA1c),shorter LTL and tended to had less mtDNAcn. In correlation analysis, GDF15 was positively correlated with age, while LTL and mtDNAcn were negatively correlated with age.After adjusting for confounding factors,GDF15 was negatively associated with LTL (β = −0.120, 95%CI [−0.197, −0.042], p = 0.003) and the association was linear(p for nonlinear = 0.645), while the negative association between GDF15 and mtDNAcn did not reach significance.In the stratified analyses,the negative associations between GDF15 and LTL were more prominent in women, overweight individuals, or subjects with abnormal glucose tolerance (AGT), but similar results were observed in younger and older subjects.

Conclusions

This study found a linear negative association between GDF 15 and LTL,which was more prominent in women, overweight or AGT subjects.These results supported that GDF15 might be a reliable biomarker of aging.

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来源期刊

Journal of Nutrition Health & Aging 医学-老年医学

CiteScore

7.80

自引率

3.40%

发文量

136

审稿时长

4-8 weeks

期刊介绍： There is increasing scientific and clinical interest in the interactions of nutrition and health as part of the aging process. This interest is due to the important role that nutrition plays throughout the life span. This role affects the growth and development of the body during childhood, affects the risk of acute and chronic diseases, the maintenance of physiological processes and the biological process of aging. A major aim of "The Journal of Nutrition, Health & Aging" is to contribute to the improvement of knowledge regarding the relationships between nutrition and the aging process from birth to old age.