Omega-3和CoQ10作为牙周治疗辅助手段和慢性牙周炎患者唾液总抗氧化能力的比较评估：一项双盲，随机临床试验

IF 1.7 Q3 DENTISTRY, ORAL SURGERY & MEDICINE

Saudi Dental Journal Pub Date : 2024-12-01 DOI:10.1016/j.sdentj.2024.09.014

Amirhossein Farahmand , Marjan Talebi , Farzaneh Ramezani , Roghayeh Karami , Zahra Jafari Nodoushani , Neda Alsadat Ayatollahi , Seyed Abdulmajid Ayatollahi , Arezoo Alaee

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引用次数: 0

摘要

牙科界已经对Omega-3和辅酶Q10减少牙周炎症的潜力表现出兴趣。这些抗氧化剂可以提高非手术牙周治疗的效果。本研究旨在探讨辅酶q10和Omega-3补充剂在改善慢性牙周炎患者牙周健康和唾液TAC方面的潜在益处。方法在一项双盲随机临床试验中，75人被诊断为慢性牙周炎。这些人被随机分为三组。牙周检查涉及三组共300颗牙齿。用牙周探针测量与下颌骨相邻的两颗磨牙的牙周参数。所有患者均行刮治和牙根刨平。A组和B组分别给予辅酶q10和Omega-3， C组作为对照组。评估非刺激唾液样本的TAC，以评估2个月前后的任何变化。采用统计学方法比较各组间的CAL指数和PPD。结果对牙龈指数的分析表明，与辅酶q10和对照组相比，Omega-3组的炎症明显减少，减少了近30%。此外，与辅酶q10和对照组相比，Omega-3组的探查指数出血有显著改善，这种减少在统计学上是显著的。此外，与最初的测量结果相比，三组患者唾液中的TAC水平都发生了变化。结论补充Omega-3和辅酶q10对牙周健康和唾液抗氧化能力的潜在治疗作用提供了有价值的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Comparative assessment of Omega-3 and CoQ10 as adjuncts to periodontal therapy and total antioxidant capacity of saliva in patients with chronic periodontitis: A double-blind, randomized clinical trial

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Introduction

The dental community has shown interest in the potential of Omega-3 and coenzyme Q10 for reducing inflammation in the periodontium. These antioxidant agents may enhance the outcomes of non-surgical periodontal treatments. This study aimed to investigate the potential benefits of CoQ10 and Omega-3 supplements in improving periodontal health and the TAC of saliva in individuals with chronic periodontitis.

Methods

In a double-blind, randomized clinical trial, 75 individuals were diagnosed with chronic periodontitis. These individuals were randomly allocated into three groups. The periodontal examination involved a total of 300 teeth across the three groups. The periodontal parameters of the two molars adjacent to the mandible were measured using a periodontal probe. All patients underwent scaling and root planing. Groups A and B received CoQ10 and Omega-3 respectively, while Group C served as the control. The TAC of the non-stimulated saliva samples was evaluated to assess any changes before and after 2 months. Statistical techniques were employed to compare the CAL index and PPD between the groups under study.

Results

The analysis of the gingival index indicated a notable reduction in inflammation within the Omega-3 group compared to both the CoQ10 and control groups, with a nearly 30% decrease observed. Furthermore, the bleeding on probing index within the Omega-3 group demonstrated significant improvements when contrasted with the CoQ10 and control groups, with this decrease being statistically significant. Additionally, the levels of TAC in the patients’ saliva across all three groups exhibited changes when compared to the initial measurements.

Conclusion

These findings provide valuable insights into the potential therapeutic effects of Omega-3 and CoQ10 supplementation on periodontal health and the antioxidant capacity of saliva.

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来源期刊

Saudi Dental Journal DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.60

自引率

0.00%

发文量

审稿时长

22 weeks

期刊介绍： Saudi Dental Journal is an English language, peer-reviewed scholarly publication in the area of dentistry. Saudi Dental Journal publishes original research and reviews on, but not limited to: • dental disease • clinical trials • dental equipment • new and experimental techniques • epidemiology and oral health • restorative dentistry • periodontology • endodontology • prosthodontics • paediatric dentistry • orthodontics and dental education Saudi Dental Journal is the official publication of the Saudi Dental Society and is published by King Saud University in collaboration with Elsevier and is edited by an international group of eminent researchers.