Strategic Synthesis of Sulfinamides as Versatile S(IV) Intermediates

Sulfinamides constitute adaptable S(IV) intermediates with a sulfur stereocenter, having emerging interest in divergent synthesis of high-valent S(VI) functional bioisosteres. Recent years have witnessed the strategic development of mild and selective synthetic routes for highly functionalized sulfinamides, employing stable organometallic reagents, carbon-centered radical precursors, and other abundant coupling partners merged with various sulfur reagents in the arena of metal, photoredox, and organocatalysis. Furthermore, asymmetric metal and organocatalysis have enabled the stereoselective synthesis of enantioenriched sulfinamides. In this Perspective, we present the recent (2021 to present) advancement of various synthetic methods toward sulfinamides.