Madison J. Wong, Kaitlyn M. Freiberg, Trevor Reynafarje Jones, Kylee B. Dismuke Rodriguez, Alex B. Wood and Bruce H. Lipshutz*,
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SNAr Reactions Using Continuous Plug Flow...in Aqueous Biphasic Media
New plug-flow opportunities for carrying out SNAr reactions are disclosed using water mixed with the green and separable/recyclable cosolvent 2-MeTHF. This approach enables C–O, C–N, and C–S bond formations. Several features characteristic of this sustainable technology are highlighted, such as recycling of the aqueous reaction medium, applications to several intermediates en route to numerous active pharmaceutical ingredients, and a new “flow-to-batch-to-flow” sequence of reactions demonstrating the possibilities for both time and pot economies to be realized.
New plug-flow opportunities for carrying out SNAr reactions are disclosed using water mixed with the green and separable/recyclable cosolvent 2-MeTHF. This approach enables C−O, C−N, and C−S bond formations. Several features characteristic of this sustainable technology are highlighted, such as recycling of the aqueous reaction medium, applications to several intermediates en route to numerous active pharmaceutical ingredients, and a new “flow-to-batch-to-flow” sequence of reactions demonstrating the possibilities for both time and pot economies to be realized.
期刊介绍：
ACS Sustainable Chemistry & Engineering is a prestigious weekly peer-reviewed scientific journal published by the American Chemical Society. Dedicated to advancing the principles of green chemistry and green engineering, it covers a wide array of research topics including green chemistry, green engineering, biomass, alternative energy, and life cycle assessment.
The journal welcomes submissions in various formats, including Letters, Articles, Features, and Perspectives (Reviews), that address the challenges of sustainability in the chemical enterprise and contribute to the advancement of sustainable practices. Join us in shaping the future of sustainable chemistry and engineering.
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