他汀类药物与早期阿尔茨海默病中较高的皮质厚度有关。

IF 4.3
Yane Zheng , Huiying Gu , Yuming Kong , Alzheimer's Disease Neuroimaging Initiative (ADNI)
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引用次数: 0

摘要

背景:大脑是胆固醇含量最高的器官,对髓鞘形成和神经元功能至关重要。他汀类药物,广泛用于降低胆固醇,穿过血脑屏障,可能影响脑胆固醇合成。尽管他汀类药物被广泛使用,但其对与阿尔茨海默病(AD)相关的皮质区域的影响尚不清楚。本研究旨在比较他汀暴露和未暴露的老年人的皮质厚度,并评估他汀类药物潜在的神经保护作用。方法:数据来自阿尔茨海默病神经影像学倡议(ADNI)。样本包括193名健康对照(HC)、485名轻度认知障碍(MCI)患者和169名阿尔茨海默病(AD)患者。如果参与者使用他汀类药物至少两年,则被归类为他汀类药物使用者。使用FreeSurfer软件对MRI数据进行处理,以估计64个感兴趣区域的皮质厚度。ANCOVA模型评估了基线时他汀类药物使用与皮质厚度之间的关系,线性混合模型评估了纵向变化。结果:在HC、MCI和AD参与者中,他汀类药物的使用与多个脑区皮质厚度增加有关。在HC中,他汀类药物使用者在右侧枕外侧、左侧颞中部和左侧海马旁区有更大的厚度。MCI参与者在右侧楔骨、右侧后扣带和左侧颞上皮层表现出额外的增加。在AD患者中,他汀类药物服用者右侧楔叶和右侧顶叶上小叶的厚度更高。纵向分析显示,HC组和AD组的皮质厚度变化没有他汀类药物相关的差异,但在MCI中,他汀类药物减缓了左内侧眶额皮质皮质变薄。结论:他汀类药物的使用与老年人皮质厚度增加有关,尤其是轻度认知障碍患者。这些发现表明他汀类药物可能具有神经保护作用,可能减轻早期认知能力下降的神经退行性变化。进一步的研究需要更大的队列和更长的随访期来证实这些发现并了解所涉及的机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Statin is associated with higher cortical thickness in early Alzheimer's disease

Background

The brain is the most cholesterol-rich organ, essential for myelination and neuronal function. Statins, widely used to lower cholesterol, cross the blood-brain barrier and may impact brain cholesterol synthesis. Despite their widespread use, the effects of statins on cortical regions relevant to Alzheimer's disease (AD) are not well understood. This study aimed to compare cortical thickness between statin-exposed and statin-unexposed older adults and evaluate the potential neuroprotective effects of statins.

Methods

Data were obtained from the Alzheimer's Disease Neuroimaging Initiative (ADNI). The sample included 193 healthy controls (HC), 485 individuals with mild cognitive impairment (MCI), and 169 individuals with Alzheimer's disease (AD). Participants were categorized as statin users if they had used statins for at least two years. MRI data were processed using FreeSurfer software to estimate cortical thickness in 64 regions of interest. ANCOVA models assessed the association between statin use and cortical thickness at baseline, and linear mixed models evaluated longitudinal changes.

Results

Statin use was associated with increased cortical thickness in multiple brain regions across HC, MCI, and AD participants. In HC, statin users had greater thickness in the right lateral occipital, left middle temporal, and left parahippocampal regions. MCI participants exhibited additional increases in the right cuneus, right posterior cingulate, and left superior temporal cortex. In AD, statin users had higher thickness in the right cuneus and right superior parietal lobule. Longitudinal analysis revealed no statin-related differences in cortical thickness changes among HC and AD groups, but in MCI, statins slowed cortical thinning in the left medial orbitofrontal cortex.

Conclusion

Statin use is associated with greater cortical thickness in older adults, particularly in those with MCI. These findings suggest that statins may have neuroprotective effects, potentially mitigating neurodegenerative changes in early cognitive decline. Further research with larger cohorts and longer follow-up periods is needed to confirm these findings and understand the mechanisms involved.
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来源期刊
Experimental gerontology
Experimental gerontology Ageing, Biochemistry, Geriatrics and Gerontology
CiteScore
6.70
自引率
0.00%
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审稿时长
66 days
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