Aliasghar Fakhri-Demeshghieh, Hamideh Hasannejad, Parniyan Khoramian, Vahid Rahmanian, Alireza Bahonar
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Risk of bias assessment was assessed with Appraisal tool for Cross-Sectional Studies. For meta-analysis, a random effects model with Freeman-Tukey double arcsine transformation was used. Subgroup analysis for the year of publication and sensitivity analysis to assess the influence of individual studies were conducted and a province-level map of point estimates was drawn.</p><p><strong>Results: </strong>Among 13 included studies, the pooled tetracycline resistance was 85% (95% CI: 76-92%) and I-squared was 94.29%. In subgroup analysis, resistance rate was higher for articles published in 2018-2023 (91%) compared to articles published in 2013-2017 (76%), but heterogeneity between groups was not statistically-significant (<i>P</i>=0.12). sensitivity analysis showed that the omission of individual studies caused no apparent change. The province-level map showed that most of the studies belonged to northern parts of Iran with Ardabil (99.65%) having the highest value.</p><p><strong>Conclusion: </strong>Resistance against tetracycline in <i>E. coli</i> isolates from broilers in Iran is alarming. 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Antibiotics such as tetracycline are an important treatment choice for colibacillosis in Iran. However, the irrational use of antibiotics has caused high antibiotic resistance. The aim of this study was to estimate the tetracycline resistance rate among <i>E. coli</i> isolates from broilers in Iran.</p><p><strong>Methods: </strong>PubMed, Scopus, Web of Science, Google Scholar, Islamic World Science Citation, Scientific Information Database, and MagIran databases were searched from 2013 and 2023. Risk of bias assessment was assessed with Appraisal tool for Cross-Sectional Studies. For meta-analysis, a random effects model with Freeman-Tukey double arcsine transformation was used. Subgroup analysis for the year of publication and sensitivity analysis to assess the influence of individual studies were conducted and a province-level map of point estimates was drawn.</p><p><strong>Results: </strong>Among 13 included studies, the pooled tetracycline resistance was 85% (95% CI: 76-92%) and I-squared was 94.29%. In subgroup analysis, resistance rate was higher for articles published in 2018-2023 (91%) compared to articles published in 2013-2017 (76%), but heterogeneity between groups was not statistically-significant (<i>P</i>=0.12). sensitivity analysis showed that the omission of individual studies caused no apparent change. The province-level map showed that most of the studies belonged to northern parts of Iran with Ardabil (99.65%) having the highest value.</p><p><strong>Conclusion: </strong>Resistance against tetracycline in <i>E. coli</i> isolates from broilers in Iran is alarming. 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引用次数: 0
摘要
背景：禽大肠杆菌病是由禽致病性大肠杆菌引起的感染，具有高发病率、高死亡率和重大经济损失。四环素等抗生素是伊朗大肠杆菌病的重要治疗选择。然而，抗生素的不合理使用造成了抗生素的高度耐药性。本研究的目的是估计伊朗肉鸡大肠杆菌分离株的四环素耐药率。方法：检索2013 ~ 2023年的PubMed、Scopus、Web of Science、谷歌Scholar、Islamic World Science Citation、Scientific Information Database和MagIran数据库。偏倚风险评估采用横断面研究评估工具进行。meta分析采用Freeman-Tukey双反正弦变换随机效应模型。进行了发表年份的亚组分析和敏感性分析，以评估个别研究的影响，并绘制了省级点估计值图。结果：纳入的13项研究中，四环素耐药率为85% (95% CI: 76 ~ 92%)， i²为94.29%。亚组分析中，2018-2023年发表的文献耐药率（91%）高于2013-2017年发表的文献（76%），但组间异质性无统计学意义（P=0.12）。敏感性分析表明，个别研究的遗漏没有引起明显的变化。省级地图显示，大多数研究属于伊朗北部地区，其中Ardabil（99.65%）的价值最高。结论：伊朗肉鸡大肠杆菌对四环素的耐药性令人担忧。建议合理使用四环素。
Tetracycline Resistance among Escherichia coli Isolates from Broilers in Iran: A Systematic Review and Meta-Analysis.
Background: Avian colibacillosis are infections caused by Avian Pathogenic Escherichia coli which causes high morbidity, high mortality, and significant economic losses. Antibiotics such as tetracycline are an important treatment choice for colibacillosis in Iran. However, the irrational use of antibiotics has caused high antibiotic resistance. The aim of this study was to estimate the tetracycline resistance rate among E. coli isolates from broilers in Iran.
Methods: PubMed, Scopus, Web of Science, Google Scholar, Islamic World Science Citation, Scientific Information Database, and MagIran databases were searched from 2013 and 2023. Risk of bias assessment was assessed with Appraisal tool for Cross-Sectional Studies. For meta-analysis, a random effects model with Freeman-Tukey double arcsine transformation was used. Subgroup analysis for the year of publication and sensitivity analysis to assess the influence of individual studies were conducted and a province-level map of point estimates was drawn.
Results: Among 13 included studies, the pooled tetracycline resistance was 85% (95% CI: 76-92%) and I-squared was 94.29%. In subgroup analysis, resistance rate was higher for articles published in 2018-2023 (91%) compared to articles published in 2013-2017 (76%), but heterogeneity between groups was not statistically-significant (P=0.12). sensitivity analysis showed that the omission of individual studies caused no apparent change. The province-level map showed that most of the studies belonged to northern parts of Iran with Ardabil (99.65%) having the highest value.
Conclusion: Resistance against tetracycline in E. coli isolates from broilers in Iran is alarming. The sensible use of tetracycline is advised.
期刊介绍：
Iranian Journal of Public Health has been continuously published since 1971, as the only Journal in all health domains, with wide distribution (including WHO in Geneva and Cairo) in two languages (English and Persian). From 2001 issue, the Journal is published only in English language. During the last 41 years more than 2000 scientific research papers, results of health activities, surveys and services, have been published in this Journal. To meet the increasing demand of respected researchers, as of January 2012, the Journal is published monthly. I wish this will assist to promote the level of global knowledge. The main topics that the Journal would welcome are: Bioethics, Disaster and Health, Entomology, Epidemiology, Health and Environment, Health Economics, Health Services, Immunology, Medical Genetics, Mental Health, Microbiology, Nutrition and Food Safety, Occupational Health, Oral Health. We would be very delighted to receive your Original papers, Review Articles, Short communications, Case reports and Scientific Letters to the Editor on the above mentioned research areas.
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