Pubertal timing, depressive symptoms, and depression in adolescent males: a prospective cohort study.

Background: Early pubertal timing is associated with depressive symptoms in girls, but studies in boys are limited and have yielded conflicting results.

Methods: N = 4,664 male participants from a UK birth cohort (Avon Longitudinal Study of Parents and Children - ALSPAC). Seven indicators of pubertal timing were measured repeatedly from 7 to 17 years (age at: peak height velocity, peak weight velocity, peak bone mineral content velocity, Tanner stage 3 pubic hair, Tanner stage 3 genitalia, axillary hair, and voice break), categorised into 'early', 'on-time,' and 'late' (mean ± 1 SD). Depressive symptoms (binary variable indicating higher versus lower levels) were assessed at 14 and 18 years, and depression (ICD-10 diagnosis) was assessed at 18 years. Multivariable logistic regression was used to examine associations between each indicator of pubertal timing and depressive symptoms/depression, adjusted for socioeconomic status (SES) and prepubertal body mass index (BMI).

Results: Compared to males with normative pubertal development, the odds of depression at age 18 were higher in those with early age at peak height velocity (OR: 2.06; 95% CI 1.27-3.34), early age at peak weight velocity (OR: 2.10; 95% CI 1.16-3.79), and early age at Tanner genitalia stage 3 (OR: 1.81; 95% CI 1.01-3.26). There was no evidence for associations between pubertal timing and depressive symptoms at age 14 or 18.

Conclusions: We found evidence that males with an earlier pubertal timing had increased odds of depression at age 18. Early maturing boys could be targeted for interventions aimed at preventing depression.