Lukas Jakob Moser, Konstantin Klambauer, Maria Carolina Diaz Machicado, Diana Frey, Victor Mergen, Matthias Eberhard, Tristan Nowak, Bernhard Schmidt, Thomas Flohr, Oliver Distler, Hatem Alkadhi
{"title":"利用光子计数检测器CT的光谱定位x线片评估体内骨密度：与DXA的前瞻性比较。","authors":"Lukas Jakob Moser, Konstantin Klambauer, Maria Carolina Diaz Machicado, Diana Frey, Victor Mergen, Matthias Eberhard, Tristan Nowak, Bernhard Schmidt, Thomas Flohr, Oliver Distler, Hatem Alkadhi","doi":"10.1097/RLI.0000000000001159","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this study was to determine in a prospective patient study the accuracy of areal bone mineral density (aBMD) measurements with spectral localizer radiographs obtained with a clinical photon-counting detector computed tomography (PCD-CT) scanner in comparison with dual-energy x-ray absorptiometry (DXA).</p><p><strong>Methods: </strong>In this institutional review board-approved, prospective study, 41 patients (15 females, 26 males; mean age 61.3 years, age range 35-78 years) underwent PCD-CT of the abdomen with a spectral localizer radiograph (tube voltage 140 kVp, tube current 30 mA) and DXA within a median of 45 days. aBMD values were derived for lumbar vertebrae L1-L4 from both methods and were compared with linear regression, Pearson correlation, intraclass correlation coefficients (ICCs), and Bland-Altman plots. T-scores were calculated on a patient level and were compared between methods.</p><p><strong>Results: </strong>DXA and spectral localizer radiographs showed strong correlation in aBMD measurements (R = 0.97, P < 0.001) and patient level T-scores (R = 0.99, P < 0.001). There was a strong agreement between aBMD from both methods (ICC, 0.96; 95% CI, 0.94-0.97). Bland-Altman analysis revealed a very small mean difference in aBMD between methods (mean absolute error 0.019 g/cm2) with narrow limits of agreement (-0.083 g/cm2 to 0.121 g/cm2). Similarly, there were small differences in regard to the T-score (mean absolute error 0.156) with narrow limits of agreement (-0.422 to 0.734) between methods. ICCs indicated an excellent agreement between T-scores from DXA and spectral localizer radiographs (ICC, 0.98; 95% confidence interval, 0.95-0.99).</p><p><strong>Conclusions: </strong>Our prospective patient study indicates that spectral localizer radiographs obtained with a clinical PCD-CT system enable accurate quantification of the lumbar bone areal mineral density. This opens up the opportunity for opportunistic screening of osteoporosis in patients who undergo CT for other indications.</p>","PeriodicalId":14486,"journal":{"name":"Investigative Radiology","volume":" ","pages":""},"PeriodicalIF":7.0000,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"In Vivo Bone Mineral Density Assessment With Spectral Localizer Radiographs From Photon-Counting Detector CT: Prospective Comparison With DXA.\",\"authors\":\"Lukas Jakob Moser, Konstantin Klambauer, Maria Carolina Diaz Machicado, Diana Frey, Victor Mergen, Matthias Eberhard, Tristan Nowak, Bernhard Schmidt, Thomas Flohr, Oliver Distler, Hatem Alkadhi\",\"doi\":\"10.1097/RLI.0000000000001159\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>The aim of this study was to determine in a prospective patient study the accuracy of areal bone mineral density (aBMD) measurements with spectral localizer radiographs obtained with a clinical photon-counting detector computed tomography (PCD-CT) scanner in comparison with dual-energy x-ray absorptiometry (DXA).</p><p><strong>Methods: </strong>In this institutional review board-approved, prospective study, 41 patients (15 females, 26 males; mean age 61.3 years, age range 35-78 years) underwent PCD-CT of the abdomen with a spectral localizer radiograph (tube voltage 140 kVp, tube current 30 mA) and DXA within a median of 45 days. aBMD values were derived for lumbar vertebrae L1-L4 from both methods and were compared with linear regression, Pearson correlation, intraclass correlation coefficients (ICCs), and Bland-Altman plots. T-scores were calculated on a patient level and were compared between methods.</p><p><strong>Results: </strong>DXA and spectral localizer radiographs showed strong correlation in aBMD measurements (R = 0.97, P < 0.001) and patient level T-scores (R = 0.99, P < 0.001). There was a strong agreement between aBMD from both methods (ICC, 0.96; 95% CI, 0.94-0.97). Bland-Altman analysis revealed a very small mean difference in aBMD between methods (mean absolute error 0.019 g/cm2) with narrow limits of agreement (-0.083 g/cm2 to 0.121 g/cm2). Similarly, there were small differences in regard to the T-score (mean absolute error 0.156) with narrow limits of agreement (-0.422 to 0.734) between methods. ICCs indicated an excellent agreement between T-scores from DXA and spectral localizer radiographs (ICC, 0.98; 95% confidence interval, 0.95-0.99).</p><p><strong>Conclusions: </strong>Our prospective patient study indicates that spectral localizer radiographs obtained with a clinical PCD-CT system enable accurate quantification of the lumbar bone areal mineral density. This opens up the opportunity for opportunistic screening of osteoporosis in patients who undergo CT for other indications.</p>\",\"PeriodicalId\":14486,\"journal\":{\"name\":\"Investigative Radiology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":7.0000,\"publicationDate\":\"2025-02-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Investigative Radiology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1097/RLI.0000000000001159\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Investigative Radiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/RLI.0000000000001159","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
引用次数: 0
摘要
目的：本研究的目的是在一项前瞻性患者研究中确定用临床光子计数检测器计算机断层扫描（PCD-CT）扫描仪获得的光谱定位器x线片测量面骨矿物质密度（aBMD）的准确性，并与双能x线吸收仪（DXA）进行比较。方法：在这项机构审查委员会批准的前瞻性研究中，41例患者(女性15例，男性26例；平均年龄61.3岁，年龄范围35-78岁)，在平均45天内接受了腹部PCD-CT和光谱定位片（管电压140 kVp，管电流30 mA）和DXA。从两种方法中得出L1-L4腰椎的aBMD值，并与线性回归、Pearson相关、类内相关系数（ICCs）和Bland-Altman图进行比较。t评分在患者水平上计算，并在不同方法之间进行比较。结果：DXA和光谱定位片显示aBMD测量值（R = 0.97, P < 0.001）与患者水平t评分（R = 0.99, P < 0.001）有很强的相关性。两种方法的aBMD结果非常吻合(ICC, 0.96；95% ci, 0.94-0.97)。Bland-Altman分析显示，两种方法的aBMD平均差异非常小（平均绝对误差为0.019 g/cm2），一致性范围很窄（-0.083 g/cm2至0.121 g/cm2）。同样，两种方法之间的t分数（平均绝对误差0.156）也有很小的差异，一致性范围很窄（-0.422至0.734）。ICCs表明DXA和光谱定位器x线片的t分数之间的一致性非常好(ICC, 0.98；95%置信区间为0.95-0.99)。结论：我们的前瞻性患者研究表明，临床PCD-CT系统获得的光谱定位x线片可以准确量化腰椎骨面矿物质密度。这为接受CT检查的骨质疏松症患者的其他适应症提供了机会。
In Vivo Bone Mineral Density Assessment With Spectral Localizer Radiographs From Photon-Counting Detector CT: Prospective Comparison With DXA.
Purpose: The aim of this study was to determine in a prospective patient study the accuracy of areal bone mineral density (aBMD) measurements with spectral localizer radiographs obtained with a clinical photon-counting detector computed tomography (PCD-CT) scanner in comparison with dual-energy x-ray absorptiometry (DXA).
Methods: In this institutional review board-approved, prospective study, 41 patients (15 females, 26 males; mean age 61.3 years, age range 35-78 years) underwent PCD-CT of the abdomen with a spectral localizer radiograph (tube voltage 140 kVp, tube current 30 mA) and DXA within a median of 45 days. aBMD values were derived for lumbar vertebrae L1-L4 from both methods and were compared with linear regression, Pearson correlation, intraclass correlation coefficients (ICCs), and Bland-Altman plots. T-scores were calculated on a patient level and were compared between methods.
Results: DXA and spectral localizer radiographs showed strong correlation in aBMD measurements (R = 0.97, P < 0.001) and patient level T-scores (R = 0.99, P < 0.001). There was a strong agreement between aBMD from both methods (ICC, 0.96; 95% CI, 0.94-0.97). Bland-Altman analysis revealed a very small mean difference in aBMD between methods (mean absolute error 0.019 g/cm2) with narrow limits of agreement (-0.083 g/cm2 to 0.121 g/cm2). Similarly, there were small differences in regard to the T-score (mean absolute error 0.156) with narrow limits of agreement (-0.422 to 0.734) between methods. ICCs indicated an excellent agreement between T-scores from DXA and spectral localizer radiographs (ICC, 0.98; 95% confidence interval, 0.95-0.99).
Conclusions: Our prospective patient study indicates that spectral localizer radiographs obtained with a clinical PCD-CT system enable accurate quantification of the lumbar bone areal mineral density. This opens up the opportunity for opportunistic screening of osteoporosis in patients who undergo CT for other indications.
期刊介绍：
Investigative Radiology publishes original, peer-reviewed reports on clinical and laboratory investigations in diagnostic imaging, the diagnostic use of radioactive isotopes, computed tomography, positron emission tomography, magnetic resonance imaging, ultrasound, digital subtraction angiography, and related modalities. Emphasis is on early and timely publication. Primarily research-oriented, the journal also includes a wide variety of features of interest to clinical radiologists.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
