血浆microRNA-145-5p作为急性深静脉血栓的诊断生物标志物

IF 3.4 3区医学 Q2 HEMATOLOGY

Research and Practice in Thrombosis and Haemostasis Pub Date : 2025-01-01 DOI:10.1016/j.rpth.2024.102671

Christopher Antoun , Vårin Eiriksdatter Wikan , Øyvind Øverli , Thor Ueland , Gholamreza Jafari Yeganeh , Sigrid Kufaas Brækkan , Ellen Brodin , John-Bjarne Hansen

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引用次数: 0

摘要

背景：鉴定急性深静脉血栓形成（DVT）的新生物标志物，可以降低诊断成像确认或排除诊断的需要，将是有利的。microRNA-145-5p （miR-145）有可能成为急性DVT的诊断标志物，但其诊断性能尚未在连续转诊的疑似DVT患者中进行评估。目的：本研究的目的是评估miR-145在诊断急性下肢深静脉血栓中的诊断性能。方法：纳入2021年6月至2023年7月期间因怀疑急性深静脉血栓而连续转诊至挪威Akershus大学医院急诊室的患者。入院24小时内采血评估血浆miR-145（指标试验），并采用全腿压缩超声（参考标准）确认或排除DVT。采用Cohen效应大小和受试者工作曲线下面积（AUC）来估计miR-145和d -二聚体的诊断性能。结果：在360例纳入的患者中，101例（28%）诊断为DVT。miR-145表现出较差的诊断性能，其Cohen’s d为-0.002 (95% CI, -0.241至0.216)，AUC为0.59 （95% CI, 0.51-0.67）。对于d -二聚体，Cohen’s d为1.66 (95% CI, 1.43-1.89)， AUC为0.92 （95% CI, 0.86-0.96）。结论：血浆miR-145水平对有下肢深静脉血栓临床体征和症状的急诊患者的下肢急性深静脉血栓诊断能力较差。

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Plasma microRNA-145-5p as a diagnostic biomarker for acute deep vein thrombosis

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Plasma microRNA-145-5p as a diagnostic biomarker for acute deep vein thrombosis

Background

Identification of new biomarkers for acute deep vein thrombosis (DVT) that could lower the need for diagnostic imaging to confirm or rule out the diagnosis would be advantageous. microRNA-145-5p (miR-145) has the potential to be a diagnostic marker for acute DVT, but its diagnostic performance has not been evaluated in consecutive patients referred to the hospital with suspected DVT.

Objectives

The aim of this study was to assess the diagnostic performance of miR-145 for the diagnosis of acute lower extremity DVT.

Methods

Patients consecutively referred to the emergency room at Akershus University Hospital (Norway) due to suspicion of acute DVT between June 2021 and July 2023 were included. Within 24 hours of admission, blood was collected for assessment of plasma miR-145 (index test), and whole-leg compression ultrasound (reference standard) was used to confirm or rule out DVT. Cohen’s d effect size and area under the receiver operating curve (AUC) were used to estimate the diagnostic performance of miR-145 and D-dimer.

Results

Among 360 included patients, 101 (28%) were diagnosed with DVT. miR-145 showed poor diagnostic performance, as indicated by a Cohen’s d of −0.002 (95% CI, −0.241 to 0.216) and an AUC of 0.59 (95% CI, 0.51-0.67). For D-dimer, Cohen’s d was 1.66 (95% CI, 1.43-1.89), and the AUC was 0.92 (95% CI, 0.86-0.96).

Conclusion

Plasma levels of miR-145 showed poor diagnostic performance for lower extremity acute DVT among persons referred to the emergency room with clinical signs and symptoms of DVT.

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