ApoE Ɛ4等位基因携带者阿尔茨海默病[3H]UCB-J结合水平升高

IF 2.5 4区医学 Q3 NEUROSCIENCES

Neuroscience Letters Pub Date : 2025-02-01 DOI:10.1016/j.neulet.2025.138135

Jens D. Mikkelsen , Phoebe Linde-Atkins , Burcu A. Pazarlar

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引用次数: 0

摘要

在阿尔茨海默病（AD）的发展过程中可以看到神经元和突触的损失。因此，在AD患者的额叶皮质中，使用选择性放射配体[3H]UCB-J与突触囊泡糖蛋白2A （SV2A）的结合被发现减少。我们在这里报道，SV2A结合的减少仅在不携带ApoE α 4等位基因的患者中高度显著。相比之下，携带一个或两个ApoE α 4等位基因的个体的SV2A结合水平与对照组没有差异。由于ApoE4是重要的遗传风险，与晚发性AD密切相关，因此本研究提出了与SV2A、突触丢失和功能之间有趣且意想不到的新关联。

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Higher level of [3H]UCB-J binding in ApoE Ɛ4 allele carriers with Alzheimer disease

Neuronal and synapse losses are seen under the progression of Alzheimer’s disease (AD). Accordingly, the binding to the synaptic vesicle glycoprotein 2A (SV2A) using the selective radioligand [³H]UCB-J was found to be reduced in frontal cortex from patients with AD. We report here that the reduction in SV2A binding is highly significant only in patients not carrying the ApoE ɛ4 allele. By contrast, those individuals with one or two ApoE ɛ4 alleles had SV2A binding levels not different from controls. Because ApoE4 is an important genetic risk and strongly linked to late-onset AD, this study raises an interesting new and unexpected association to SV2A, synapse loss, and function.

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来源期刊

Neuroscience Letters 医学-神经科学

CiteScore

5.20

自引率

0.00%

发文量

408

审稿时长

50 days

期刊介绍： Neuroscience Letters is devoted to the rapid publication of short, high-quality papers of interest to the broad community of neuroscientists. Only papers which will make a significant addition to the literature in the field will be published. Papers in all areas of neuroscience - molecular, cellular, developmental, systems, behavioral and cognitive, as well as computational - will be considered for publication. Submission of laboratory investigations that shed light on disease mechanisms is encouraged. Special Issues, edited by Guest Editors to cover new and rapidly-moving areas, will include invited mini-reviews. Occasional mini-reviews in especially timely areas will be considered for publication, without invitation, outside of Special Issues; these un-solicited mini-reviews can be submitted without invitation but must be of very high quality. Clinical studies will also be published if they provide new information about organization or actions of the nervous system, or provide new insights into the neurobiology of disease. NSL does not publish case reports.