SARS-CoV-2疫苗接种对长covid临床表型发展的影响

IF 2.5 4区 医学 Q3 INFECTIOUS DISEASES
Patrizia Pasculli, Michele Antonacci, Maria Antonella Zingaropoli, Federica Dominelli, Federica Ciccone, Francesco Pandolfi, Yann Collins Fosso Ngangue, Giorgio Maria Masci, Roberta Campagna, Franco Iafrate, Valeria Panebianco, Carlo Catalano, Ombretta Turriziani, Gioacchino Galardo, Paolo Palange, Claudio Maria Mastroianni, Maria Rosa Ciardi
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引用次数: 0

摘要

虽然SARS-CoV-2疫苗可以降低住院率和死亡率,但其对Long-COVID的长期影响仍有待阐明。本研究的目的是根据患者的疫苗接种情况评估长冠临床表型的不同发展。评估每位患者的临床和人口学特征,同时自我报告长期covid症状,然后将其分层为不同的临床表型。接种疫苗与避免住院、减少侵入性呼吸支持、减少心肺功能改变以及减少持续肺实质损伤显著相关。然而,未发现疫苗接种状况与至少一种长期covid症状的发展之间存在关联。然而,临床表型与疫苗接种状态的相关性不同,因为未接种疫苗的患者更常出现神经精神症状,而接种疫苗的患者大多出现心肺症状。未接种疫苗和接种疫苗的患者之间不同的血清学反应表明,不同的疾病进展可能在特定长冠临床表型的不同发展中起作用。较高的抗spike (S)抗体滴度对接种疫苗的患者具有保护作用,而对未接种疫苗的患者则有害。通过标准化的方法和症状分类,可以更好地了解covid - 19长期症状发展的机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
SARS-CoV-2 vaccination influence in the development of long-COVID clinical phenotypes.

Although SARS-CoV-2 vaccination reduces hospitalization and mortality, its long-term impact on Long-COVID remains to be elucidated. The aim of the study was to evaluate the different development of Long-COVID clinical phenotypes according to the vaccination status of patients. Clinical and demographic characteristics were assessed for each patient, while Long-COVID symptoms were self-reported and later stratified into distinct clinical phenotypes. Vaccination was significantly associated with the avoidance of hospitalization, less invasive respiratory support, and less alterations of cardiopulmonary functions, as well as reduced lasting lung parenchymal damage. However, no association between vaccination status and the development of at least one Long-COVID symptom was found. Nevertheless, clinical phenotypes were differently associated with vaccination status, as neuropsychiatric were more frequent in unvaccinated patients and cardiorespiratory symptoms were reported mostly in vaccinated patients. Different progression of disease could be at play in the different development of specific Long-COVID clinical phenotypes, as shown by the different serological responses between unvaccinated and vaccinated patients. A higher anti-Spike (S) antibody titre was protective for vaccinated patients, while it was detrimental for unvaccinated patients. A better understanding of the mechanism underlying the development of Long-COVID symptoms might be reached by standardized methodologies and symptom classification.

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来源期刊
Epidemiology and Infection
Epidemiology and Infection 医学-传染病学
CiteScore
4.10
自引率
2.40%
发文量
366
审稿时长
3-6 weeks
期刊介绍: Epidemiology & Infection publishes original reports and reviews on all aspects of infection in humans and animals. Particular emphasis is given to the epidemiology, prevention and control of infectious diseases. The scope covers the zoonoses, outbreaks, food hygiene, vaccine studies, statistics and the clinical, social and public-health aspects of infectious disease, as well as some tropical infections. It has become the key international periodical in which to find the latest reports on recently discovered infections and new technology. For those concerned with policy and planning for the control of infections, the papers on mathematical modelling of epidemics caused by historical, current and emergent infections are of particular value.
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