二甲双胍改性硅化胶原支架促进糖尿病大鼠的骨修复（Adv. Healthcare Mater.）

IF 10 2区医学 Q1 ENGINEERING, BIOMEDICAL

Advanced Healthcare Materials Pub Date : 2025-01-27 DOI:10.1002/adhm.202570019

Yi-Rong Wang, Xiao-Xia Zhang, Xu-Xu Chen, Xin-Hua Yin, Ming Yang, Kuo Jiang, Shi-Chang Liu

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摘要

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Enhancement of Bone Repair in Diabetic Rats with Metformin-Modified Silicified Collagen Scaffolds (Adv. Healthcare Mater. 3/2025)

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Enhancement of Bone Repair in Diabetic Rats with Metformin-Modified Silicified Collagen Scaffolds (Adv. Healthcare Mater. 3/2025)

Bionic Collagen Materials

In article 2401430, Yi-Rong Wang, Shi-Chang Liu, and co-workers used a biomimetic silicification principle to prepare a metformin-modified silicified collagen material. This material has been shown to promote mitochondrial autophagy by regulating the AMPK/m-TOR signaling pathway, reducing reactive oxygen species (ROS) levels, and improving the oxidation-reduction balance. It has been demonstrated to aid in the repair of diabetic bone defects. The cover design is inspired by the legendary Chinese tale of Jingwei Filling the Sea, symbolizing the bone regeneration process as Jingwei's efforts to fill the sea, which helps heal diabetic bone defects.

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来源期刊

Advanced Healthcare Materials 工程技术-生物材料

CiteScore

14.40

自引率

3.00%

发文量

600

审稿时长

1.8 months

期刊介绍： Advanced Healthcare Materials, a distinguished member of the esteemed Advanced portfolio, has been dedicated to disseminating cutting-edge research on materials, devices, and technologies for enhancing human well-being for over ten years. As a comprehensive journal, it encompasses a wide range of disciplines such as biomaterials, biointerfaces, nanomedicine and nanotechnology, tissue engineering, and regenerative medicine.