圆锥角膜从角膜变性到全身性疾病：治疗的意义

IF 3 3区医学 Q1 OPHTHALMOLOGY

Acta Ophthalmologica Pub Date : 2025-01-19 DOI:10.1111/aos.16848

Giulio Ferrari

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引用次数: 0

摘要

圆锥角膜传统上被认为是一种眼部疾病，特别是一种非炎症性角膜变性。然而，高达50%的病例与圆锥角膜相关的系统性合并症，最近的证据表明，营养/代谢失衡是疾病发病机制中相关的，也许是不可或缺的辅助因素。在这里，我们将回顾当前的证据，以及我们最近的数据，支持一个具有挑衅性的假设：圆锥角膜是一种全身性疾病的眼部表现。

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Keratoconus from corneal degeneration to systemic disease: implications for treatment

Keratoconus has been traditionally considered an ocular disaese, and, specifically, a non-inflammatory corneal degeneration.

However, systemic comorbidities are associated with keratoconus in up to 50% of cases, and recent evidence is emerging that nutritional/metabolic inbalances are associated, and perhaps indispensable, co-factors in disease pathogenesis.

Here, we will provide a review of current evidence, and our recent data, supporting a provocative hypothesis: keratoconus is the ocular manifestation of a systemic disease.

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来源期刊

Acta Ophthalmologica 医学-眼科学

CiteScore

7.60

自引率

5.90%

发文量

433

审稿时长

6 months

期刊介绍： Acta Ophthalmologica is published on behalf of the Acta Ophthalmologica Scandinavica Foundation and is the official scientific publication of the following societies: The Danish Ophthalmological Society, The Finnish Ophthalmological Society, The Icelandic Ophthalmological Society, The Norwegian Ophthalmological Society and The Swedish Ophthalmological Society, and also the European Association for Vision and Eye Research (EVER). Acta Ophthalmologica publishes clinical and experimental original articles, reviews, editorials, educational photo essays (Diagnosis and Therapy in Ophthalmology), case reports and case series, letters to the editor and doctoral theses.