封面：影响DNA g -四重体RGG肽液-液相分离的因素（ChemMedChem 2/2025）

IF 3.6 4区医学 Q2 CHEMISTRY, MEDICINAL

ChemMedChem Pub Date : 2025-01-14 DOI:10.1002/cmdc.202580201

Sumit Shil, Mitsuki Tsuruta, Keiko Kawauchi, Daisuke Miyoshi

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引用次数: 0

摘要

封面图显示了精氨酸残基在g -四联体（G4）介导的液-液相分离（LLPS）中的关键作用。可视化表示显示RGG肽与G4-DNA相互作用，形成LLPS液滴。该艺术突出了精氨酸对LLPS的特定相互作用的重要性，反映了该研究对驱动G4-LLPS的分子机制的见解。更多细节可以在10.1002/cmdc中找到。202400460作者：Daisuke Miyoshi和同事。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Front Cover: Factors Affecting Liquid-Liquid Phase Separation of RGG Peptides with DNA G-Quadruplex (ChemMedChem 2/2025)

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Front Cover: Factors Affecting Liquid-Liquid Phase Separation of RGG Peptides with DNA G-Quadruplex (ChemMedChem 2/2025)

The front cover picture shows the critical role of arginine residues in G-quadruplex (G4) mediated liquid-liquid phase separation (LLPS). A visual representation shows an RGG peptide interacting with G4-DNA, forming LLPS droplets. The art highlights the importance of arginine′s specific interactions for LLPS, reflecting the study's insights into the molecular mechanisms driving G4-LLPS. More details can be found in article 10.1002/cmdc.202400460 by Daisuke Miyoshi and co-workers.

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来源期刊

ChemMedChem 医学-药学

CiteScore

6.70

自引率

2.90%

发文量

280

审稿时长

1 months

期刊介绍： Quality research. Outstanding publications. With an impact factor of 3.124 (2019), ChemMedChem is a top journal for research at the interface of chemistry, biology and medicine. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies. ChemMedChem publishes primary as well as critical secondary and tertiary information from authors across and for the world. Its mission is to integrate the wide and flourishing field of medicinal and pharmaceutical sciences, ranging from drug design and discovery to drug development and delivery, from molecular modeling to combinatorial chemistry, from target validation to lead generation and ADMET studies. ChemMedChem typically covers topics on small molecules, therapeutic macromolecules, peptides, peptidomimetics, and aptamers, protein-drug conjugates, nucleic acid therapies, and beginning 2017, nanomedicine, particularly 1) targeted nanodelivery, 2) theranostic nanoparticles, and 3) nanodrugs. Contents ChemMedChem publishes an attractive mixture of: Full Papers and Communications Reviews and Minireviews Patent Reviews Highlights and Concepts Book and Multimedia Reviews.