具有局部和非局部混合扩散的空间May-Nowak模型的行病毒波

IF 2.6 2区 数学 Q1 MATHEMATICS, APPLIED
Jie Wang, Jinfen Guo, Chuanhui Zhu, Shuang-Ming Wang
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引用次数: 0

摘要

为了研究病毒在宿主细胞间传播的空间动力学,本文研究了具有混合传播的反应扩散系统和May-Nowak系统中病毒波的存在性和不存在性。具体来说,我们定义了一个临界波速c * $ c^{\ast }$阈值,以确定当病毒感染繁殖数R 0 &gt时是否存在行波;1 $ \mathcal {R}_{0}>1$。利用上/下解结合Schauder不动点定理,确定了在每个波速c≥c * $ c\ge c^{\ast }$时,连接未感染状态和感染状态的行波的存在性。反过来,通过应用负单侧拉普拉斯变换证明了0 &lt;C &lt;C * $ 0 < c < c^{\ast }$。还证明了r0≤1 $\mathcal {R}_{0}\le 1$情况下行波的不存在性。最后,结合实际的混合扩散特征,提出了一些新的耦合数值算法来分析病毒的传播波和模型的渐近传播速度,这有力地表明引入非局部扩散将加速病毒的感染。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Traveling Viral Waves for a Spatial May–Nowak Model with Hybrid Local and Nonlocal Dispersal

To investigate the spatial dynamics of viruses propagating between host cells, the current paper is devoted to studying the existence and nonexistence of viral waves for a reaction–diffusion and May–Nowak system with hybrid dispersal. Specifically, we define a critical wave speed c * $ c^{\ast }$ threshold to determine the existence of traveling waves when the viral infection reproduction number R 0 > 1 $ \mathcal {R}_{0}>1$ . By employing the upper/lower solutions along with the Schauder's fixed-point theorem, the existence of traveling waves connecting the uninfected and infected states is determined for each wave speed c c * $ c\ge c^{\ast }$ . Conversely, nonexistence is demonstrated through the application of the negative one-sided Laplace transform for the case 0 < c < c * $ 0 < c < c^{\ast }$ . The nonexistence of traveling waves in the R 0 1 $\mathcal {R}_{0}\le 1$ case is also demonstrated. Finally, some novel coupled numerical algorithms are developed to analyze the traveling viral waves and asymptotic spreading speed of the model on account of the actual hybrid dispersal features, which strongly shows that the introduction of nonlocal dispersal will accelerate viral infection.

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来源期刊
Studies in Applied Mathematics
Studies in Applied Mathematics 数学-应用数学
CiteScore
4.30
自引率
3.70%
发文量
66
审稿时长
>12 weeks
期刊介绍: Studies in Applied Mathematics explores the interplay between mathematics and the applied disciplines. It publishes papers that advance the understanding of physical processes, or develop new mathematical techniques applicable to physical and real-world problems. Its main themes include (but are not limited to) nonlinear phenomena, mathematical modeling, integrable systems, asymptotic analysis, inverse problems, numerical analysis, dynamical systems, scientific computing and applications to areas such as fluid mechanics, mathematical biology, and optics.
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