前封面：3 ' -Dehydroxypurpurogallin-4-Carboxamides作为甲型流感内切酶抑制剂：合成、结构-活性关系分析和蛋白质复合物的结构表征（ChemMedChem 3/2025）

IF 3.6 4区医学 Q2 CHEMISTRY, MEDICINAL

ChemMedChem Pub Date : 2025-02-04 DOI:10.1002/cmdc.202580301

Michal Kráľ, Tomáš Kotačka, Róbert Reiberger, Gabriela Panýrková, Kateřina Radilová, Zuzana Osifová, Miroslav Flieger, Jan Konvalinka, Pavel Majer, Milan Kožíšek, Aleš Machara

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引用次数: 0

摘要

这张图片显示了一个场景，其中蘑菇基序与紫胆碱衍生物的化学式相关联——秋水仙碱、茴香醇和金霉酮——蘑菇帽中的天然色素。这些化合物呈现为橙色、红色或棕色染料，与蘑菇的颜色相呼应。它也代表了秋季在欧洲流行的蘑菇季节。一个蓝色的“盾牌”象征着我们开发的purpurogalline的保护作用，它可以阻断流感内切酶，被描绘成准备切割RNA的剪刀。更多细节可以在10.1002/cmdc中找到。202400577，作者：Milan Kožíšek， alesti Machara及其同事。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Front Cover: 3’-Dehydroxypurpurogallin-4-Carboxamides as Influenza A Endonuclease Inhibitors: Synthesis, Structure-Activity Relationship Analysis, and Structural Characterization of Protein Complex (ChemMedChem 3/2025)

查看原文本刊更多论文

The image shows a scene where the mushroom motif is linked to the chemical formulas of purpurogallin derivatives – colchicine, fomenanthriol, and aurantricholone – natural pigments in mushroom caps. These compounds appear as orange, red, or brown dyes, echoing the mushrooms’ colors. It also represents the mushroom season, popular in Europe during autumn. A blue “shield” symbolizes the protective effect of our developed purpurogallines, which block influenza endonuclease, depicted as scissors ready to cleave RNA. More details can be found in article 10.1002/cmdc.202400577 by Milan Kožíšek, Aleš Machara, and co-workers.

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来源期刊

ChemMedChem 医学-药学

CiteScore

6.70

自引率

2.90%

发文量

280

审稿时长

1 months

期刊介绍： Quality research. Outstanding publications. With an impact factor of 3.124 (2019), ChemMedChem is a top journal for research at the interface of chemistry, biology and medicine. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies. ChemMedChem publishes primary as well as critical secondary and tertiary information from authors across and for the world. Its mission is to integrate the wide and flourishing field of medicinal and pharmaceutical sciences, ranging from drug design and discovery to drug development and delivery, from molecular modeling to combinatorial chemistry, from target validation to lead generation and ADMET studies. ChemMedChem typically covers topics on small molecules, therapeutic macromolecules, peptides, peptidomimetics, and aptamers, protein-drug conjugates, nucleic acid therapies, and beginning 2017, nanomedicine, particularly 1) targeted nanodelivery, 2) theranostic nanoparticles, and 3) nanodrugs. Contents ChemMedChem publishes an attractive mixture of: Full Papers and Communications Reviews and Minireviews Patent Reviews Highlights and Concepts Book and Multimedia Reviews.