内页图片

IF 5.5 1区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chinese Journal of Chemistry Pub Date : 2025-01-01 DOI:10.1002/cjoc.202590032

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引用次数: 0

摘要

宝石-二氟烯烃因其作为含氟合成构件的用途而受到高度重视，并因其在药品中的众多应用而得到认可。公开了一种通过顺序还原加氢脱卤合成3-宝石-二氟乙烯基内酰胺的锌介导的实用方法。此外，这种策略还可以产生高附加值的邻二氘化宝石-二氟烯烃，在α-和β-位置都有良好的氘(D)掺入，存在廉价的氧化氘。Hu等人在255-260页的文章中讨论了更多细节。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Inside Cover Picture

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Inside Cover Picture

gem-Difluoroalkenes are highly regarded for their use as fluorinated synthetic building blocks and are also recognized for their numerous applications in the pharmaceuticals. A practical zinc-mediated approach for the synthesis of 3-gem-difluorovinyl lactams through a sequential reductive hydrodehalogenation has been disclosed. Additionally, such a strategy could also enable the generation of the high value-added vicinal dideuterated gem-difluoroalkenes with excellent deuterium (D) incorporation at both α- and β-positions with the presence of inexpensive deuterium oxide. More details are discussed in the article by Hu et al. on pages 255—260.

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来源期刊

Chinese Journal of Chemistry 化学-化学综合

CiteScore

8.80

自引率

14.80%

发文量

422

审稿时长

1.7 months

期刊介绍： The Chinese Journal of Chemistry is an international forum for peer-reviewed original research results in all fields of chemistry. Founded in 1983 under the name Acta Chimica Sinica English Edition and renamed in 1990 as Chinese Journal of Chemistry, the journal publishes a stimulating mixture of Accounts, Full Papers, Notes and Communications in English.