SIRS流行病模型中的振荡如何受到免疫时间分布的影响

IF 1.7 4区 物理与天体物理 Q3 PHYSICS, CONDENSED MATTER
Daniel Henrik Nevermann, Claudius Gros
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引用次数: 0

摘要

常住传染病模型,如SIRS模型,可能会进入一种地方性状态,其中易感个体(S)、感染个体(I)和康复个体(R)的数量是恒定的,在这种状态下,康复个体获得了对再次感染的暂时免疫力。对于许多传染性病原体,感染动力学也可能表现出与相空间极限环相对应的周期性爆发。在SIRS模型中再现振荡的一种方法是在恢复状态中包含非指数停留时间分布。本文研究了一种具有阶跃函数核的SIRS免疫时间模型,绘制了模型的全相位图。利用核级数框架,我们能够在连续扩大步宽时识别周期性爆发的开始。我们进一步研究了暴发的形状,发现更宽的步长导致更多的正弦振荡,而更均匀的免疫时间分布与在较长时间的低感染活动后发生的更剧烈的暴发有关。我们的主要结果涉及以单一主导时间尺度为特征的恢复分布。我们还考虑了具有两个时间尺度的恢复分布,当两个或多个不同的恢复过程共存时,可以观察到这一分布。令人惊讶的是,在这种情况下,两个性质不同的极限环是稳定的,两个极限环中只有一个通过标准超临界Hopf分岔出现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
How oscillations in SIRS epidemic models are affected by the distribution of immunity times

Models for resident infectious diseases, like the SIRS model, may settle into an endemic state with constant numbers of susceptible (S), infected (I) and recovered (R) individuals, where recovered individuals attain a temporary immunity to reinfection. For many infectious pathogens, infection dynamics may also show periodic outbreaks corresponding to a limit cycle in phase space. One way to reproduce oscillations in SIRS models is to include a non-exponential dwell-time distribution in the recovered state. Here, we study a SIRS model with a step-function-like kernel for the immunity time, mapping out the model’s full phase diagram. Using the kernel series framework, we are able to identify the onset of periodic outbreaks when successively broadening the step-width. We further investigate the shape of the outbreaks, finding that broader steps cause more sinusoidal oscillations while more uniform immunity time distributions are related to sharper outbreaks occurring after extended periods of low infection activity. Our main results concern recovery distributions characterized by a single dominant timescale. We also consider recovery distributions with two timescales, which may be observed when two or more distinct recovery processes co-exist. Surprisingly, two qualitatively different limit cycles are found to be stable in this case, with only one of the two limit cycles emerging via a standard supercritical Hopf bifurcation.

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来源期刊
The European Physical Journal B
The European Physical Journal B 物理-物理:凝聚态物理
CiteScore
2.80
自引率
6.20%
发文量
184
审稿时长
5.1 months
期刊介绍: Solid State and Materials; Mesoscopic and Nanoscale Systems; Computational Methods; Statistical and Nonlinear Physics
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