合成3,4-二氢- 2h -苯并[4,5]咪唑[2,1-b][1,3,4]噻二嗪的简易方法

IF 1.6 3区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Journal of Sulfur Chemistry Pub Date : 2024-11-01 DOI:10.1080/17415993.2024.2394627

Evgeniya Khodykina , Diana Pobedinskaya , Inna Borodkina , Alexander Astakhov , Oleg Demidov , Anatoly Metelitsa , Victor Chernyshev , Alexandra Kolodina

引用次数: 0

摘要

通过碱催化2-芳基甲基硫代- n -芳基芳基- 1h -苯并[d]咪唑-1胺的分子内环化合成了新型2,3-二烷基-3,4-二氢- 2h -苯并[4,5]咪唑[2,1-b][1,3,4]噻嗪。碱的使用对噻嗪环的环化至关重要。在没有强碱的情况下，起始化合物进行脱胺反应，消除苯腈，形成2-芳基甲基硫苯并咪唑。

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A facile approach to the synthesis of 3,4-dihydro-2H-benzo[4,5]imidazo[2,1-b][1,3,4]thiadiazines

An efficient approach to the synthesis of novel 2,3-diaryl-3,4-dihydro-2H-benzo[4,5]imidazo[2,1-b][1,3,4]thiadiazines via a base-catalyzed intramolecular cyclization of 2-arylmethylthio-N-arylidene-1H-benzo[d]imidazol-1-amines has been developed. The use of alkali is critical for the annulation of the thiadiazine ring. In the absence of strong bases, the starting compounds undergo deamination with elimination of benzonitrile and formation of 2-arylmethylthiobenzimidazoles.

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来源期刊

Journal of Sulfur Chemistry CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

4.10

自引率

9.10%

发文量

审稿时长

6-12 weeks

期刊介绍： The Journal of Sulfur Chemistry is an international journal for the dissemination of scientific results in the rapidly expanding realm of sulfur chemistry. The journal publishes high quality reviews, full papers and communications in the following areas: organic and inorganic chemistry, industrial chemistry, materials and polymer chemistry, biological chemistry and interdisciplinary studies directly related to sulfur science. Papers outlining theoretical, physical, mechanistic or synthetic studies pertaining to sulfur chemistry are welcome. Hence the target audience is made up of academic and industrial chemists with peripheral or focused interests in sulfur chemistry. Manuscripts that truly define the aims of the journal include, but are not limited to, those that offer: a) innovative use of sulfur reagents; b) new synthetic approaches to sulfur-containing biomolecules, materials or organic and organometallic compounds; c) theoretical and physical studies that facilitate the understanding of sulfur structure, bonding or reactivity; d) catalytic, selective, synthetically useful or noteworthy transformations of sulfur containing molecules; e) industrial applications of sulfur chemistry; f) unique sulfur atom or molecule involvement in interfacial phenomena; g) descriptions of solid phase or combinatorial methods involving sulfur containing substrates. Submissions pertaining to related atoms such as selenium and tellurium are also welcome. Articles offering routine heterocycle formation through established reactions of sulfur containing substrates are outside the scope of the journal.