脂质体：弥合从实验室到药物的差距

IF 7 2区化学 Q1 CHEMISTRY, PHYSICAL

Current Opinion in Colloid & Interface Science Pub Date : 2025-02-01 DOI:10.1016/j.cocis.2024.101875

Remo Eugster, Paola Luciani

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引用次数: 0

摘要

脂质体是一种多功能的、有效的药物输送系统，在各种医学应用中得到了突出的应用。其良好定义的双层结构适用于不同化学性质的药物的包封和各种释放策略。了解脂质体的自组装和结构对提高药物开发和给药效率至关重要。在这里，我们回顾了脂质体的自组装过程，并将这些知识转移到生产手段上。讨论了规模化生产脂质体的挑战和机遇。概述了表征颗粒，其界面和组成的关键技术，这对市场批准至关重要。提出了新的计算方法来深化界面脂质行为和加速脂质体的发展，包括利用人工智能支持脂质体生产的观点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Liposomes: Bridging the gap from lab to pharmaceuticals

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Liposomes: Bridging the gap from lab to pharmaceuticals

Liposomes are versatile and effective drug delivery systems, as highlighted by various medical applications. Their well-defined bilayer structure is suited for the encapsulation of drugs with diverse chemical properties and for a variety of release strategies. Understanding liposome self-assembly and structure is crucial for enhancing drug development and delivery efficiency. Herein, we review the self-assembly process of liposomes and transfer this knowledge to means of production. The challenges and opportunities of scaling liposomal production are discussed. Key techniques, to characterize the particles, their interface and composition, essential for market approval, are outlined. Views on novel computational methods to deepen the lipid behavior at interfaces and accelerate liposome development are given, including opinions on using artificial intelligence to support liposome production.

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来源期刊

Current Opinion in Colloid & Interface Science 化学-物理化学

CiteScore

16.50

自引率

1.10%

发文量

审稿时长

11.3 weeks

期刊介绍： Current Opinion in Colloid and Interface Science (COCIS) is an international journal that focuses on the molecular and nanoscopic aspects of colloidal systems and interfaces in various scientific and technological fields. These include materials science, biologically-relevant systems, energy and environmental technologies, and industrial applications. Unlike primary journals, COCIS primarily serves as a guide for researchers, helping them navigate through the vast landscape of recently published literature. It critically analyzes the state of the art, identifies bottlenecks and unsolved issues, and proposes future developments. Moreover, COCIS emphasizes certain areas and papers that are considered particularly interesting and significant by the Editors and Section Editors. Its goal is to provide valuable insights and updates to the research community in these specialized areas.