具有巨细胞肝炎病理特征的药物性自身免疫性肝炎

IF 3.3 Q2 GASTROENTEROLOGY & HEPATOLOGY

Journal of Clinical and Experimental Hepatology Pub Date : 2024-12-28 DOI:10.1016/j.jceh.2024.102498

Jie Yao , Yongqin Yan, Mei Ruan, Haiyan Lin, Dongliang Li, Zhiyu Zeng

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引用次数: 0

摘要

背景与方法药物性自身免疫样肝炎（DI-ALH）与自身免疫性肝炎（AIH）的区分是一个令人困惑且具有挑战性的问题。我们报告一例以自身抗体阳性、免疫球蛋白G （IgG）水平升高和巨细胞肝炎的组织学特征为特征的DI-ALH。结果行肝活检明确病因，诊断为DI-ALH。经糖皮质激素和硫唑嘌呤治疗后，患者肝功能恢复正常，无复发。结论根据停止免疫抑制的可能性和组织学特征区分DI-ALH和AIH。临床医生需要调查患者的病史、血清学检查和病理变化，以建立正确的诊断。

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Drug-induced Autoimmune-like Hepatitis With Pathological Features of Giant Cell Hepatitis

Background and methods

The differentiation between drug-induced autoimmune-like hepatitis (DI-ALH) and autoimmune hepatitis (AIH) can be confusing and challenging. We present a case of DI-ALH characterized by positive autoantibodies, elevated immunoglobulin G (IgG) levels and histology characteristics of giant cell hepatitis.

Results

A liver biopsy was performed for etiology clarification, DI-ALH was diagnosed. Following treatment with corticosteroids and azathioprine, the patient's liver function remained normal without recurrence.

Conclusions

Distinguishing DI-ALH from AIH based on the possibility of discontinuing immunosuppression and the histological features. Clinicians need to investigate patient's medical history, serological tests, and pathological changes to establish a correct diagnosis.

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