以Mizoroki-Heck反应为关键步骤制备loxoprofen的新路线

IF 1.8 3区化学 Q3 CHEMISTRY, ORGANIC

Synthetic Communications Pub Date : 2025-02-01 DOI:10.1080/00397911.2024.2441331

Huansheng Chen , Dandan Tang , Long Lin , Wei Yuan , Yu Chen , Xianhua Pan

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引用次数: 0

摘要

本研究描述了一种新的loxoprofen制备方法。整个工艺以廉价的环戊酮和4-溴苯乙酸甲酯为原料，分为五个步骤。关键中间体由2-亚甲基环戊酮和2-（4-溴苯基）丙酸甲酯经Mizoroki-Heck反应制得。通过加氢后水解得到loxoprofen，总收率为56%，纯度为99.7%。

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New route to preparation of loxoprofen through Mizoroki-Heck reaction as the key step

The current study describes a new preparation of loxoprofen. The whole process includes five steps from cheap cyclopentanone and methyl 4-bromophenylacetate as the starting materials. The key intermediate is obtained through Mizoroki-Heck reaction of 2-methylenecyclopentanone and methyl 2-(4-bromophenyl)propanoate. The desired loxoprofen is yielded through hydrogenation followed by hydrolysis in 56% overall yield with 99.7% purity.

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来源期刊

Synthetic Communications 化学-有机化学

CiteScore

4.40

自引率

4.80%

发文量

156

审稿时长

4.3 months

期刊介绍： Synthetic Communications presents communications describing new methods, reagents, and other synthetic work pertaining to organic chemistry with sufficient experimental detail to permit reported reactions to be repeated by a chemist reasonably skilled in the art. In addition, the Journal features short, focused review articles discussing topics within its remit of synthetic organic chemistry.