COVID-19大流行期间极低出生体重早产儿的神经发育结局

IF 2.3 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Clinical Epidemiology and Global Health Pub Date : 2025-01-27 DOI:10.1016/j.cegh.2025.101940

Yen-Chen Lin , Hung-Yang Chang , Chia-Huei Chen , Jui-Hsing Chang , Wai-Tim Jim , Chyong-Hsin Hsu , Chia-Ying Lin , Yu-Xiang Song , Cheng-Wei Chen , Tzu-Yu Liu , Mary Hsin-Ju Ko

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引用次数: 0

摘要

在新冠肺炎大流行期间，台湾新生儿重症监护病房的父母参与和早产儿出院后随访有限。摘要本研究旨在探讨流感大流行对台湾早产儿神经发育的影响。方法回顾性研究，纳入两家医院2018年1月至2021年12月出生的极低出生体重（VLBW）早产儿。前covid -19组（PCG）由2018年1月至2019年4月（大流行之前）出生的VLBW婴儿组成。2019年5月以后出生并在大流行期间随访至少24个月的VLBW婴儿被分配到COVID-19组（CG）。收集并比较了参与者的产前、围产期和产后数据以及12和/或24个月校正年龄（CA）时的神经发育结果。结果研究期间共出生VLBW婴儿547例。与PCG相比，CG的住院时间和随访时间明显延长。两组在认知、语言和运动方面的综合得分没有显著差异。中度神经发育障碍（NDI）的百分比在CA 12个月时较高，但在CA 24个月时没有。重度NDI在两组间也无显著差异。结论大流行期间vlbw早产儿住院时间延长，随访时间延迟，在出生后12个月时NDI较高，对这一高危群体进行长期监测和护理至关重要。

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Neurodevelopmental outcomes of very low birth weight preterm infants during the COVID-19 pandemic

Background

During the COVID-19 pandemic, parental involvement in NICU and post-discharge follow-up for preterm infants in Taiwan were limited. This study aimed to investigate the impact of the pandemic on the neurodevelopmental outcomes of preterm infants in Taiwan.

Method

This was a retrospective study enrolling very-low-birth weight (VLBW) preterm infants born between January 2018 and December 2021 from two hospitals. The pre-COVID-19 group (PCG) consisted of VLBW infants born between January 2018 and April 2019, before the pandemic. VLBW infants born after May 2019 and followed-up for at least 24 months during the pandemic were assigned to the COVID-19 group (CG). The antenatal, perinatal, and postnatal data, and neurodevelopmental outcomes at 12 and/or 24 months corrected age (CA) of the participants were collected and compared.

Results

A total of 547 VLBW infants were born during the study period. CG had significantly longer hospital stay and delayed follow-up time compared to PCG. No significant differences were observed in the composite cognitive, language, and motor scores between two groups. The percentages of moderate neurodevelopmental impairment (NDI) were higher at 12 months CA, but not at 24 months. The severe NDI also presented no significant difference between the groups.

Conclusion

VLBW preterm infants during the pandemic had extended hospital stays and delayed follow-ups, with higher moderate NDI at 12 months CA. Long-term monitoring and care are essential for this at-risk group.

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来源期刊

Clinical Epidemiology and Global Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-

CiteScore

4.60

自引率

7.70%

发文量

218

审稿时长

66 days

期刊介绍： Clinical Epidemiology and Global Health (CEGH) is a multidisciplinary journal and it is published four times (March, June, September, December) a year. The mandate of CEGH is to promote articles on clinical epidemiology with focus on developing countries in the context of global health. We also accept articles from other countries. It publishes original research work across all disciplines of medicine and allied sciences, related to clinical epidemiology and global health. The journal publishes Original articles, Review articles, Evidence Summaries, Letters to the Editor. All articles published in CEGH are peer-reviewed and published online for immediate access and citation.