磁性纳米颗粒的可持续合成：雪松提取物的生物学应用

IF 2.4 4区物理与天体物理 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY

Current Applied Physics Pub Date : 2025-01-28 DOI:10.1016/j.cap.2025.01.015

Shilpa Kumari , Mohit Sahni , Soumya Pandit , Neha Verma , Firdaus Mohamad Hamzah , Kuldeep Sharma , Kanu Priya

{"title":"磁性纳米颗粒的可持续合成：雪松提取物的生物学应用","authors":"Shilpa Kumari , Mohit Sahni , Soumya Pandit , Neha Verma , Firdaus Mohamad Hamzah , Kuldeep Sharma , Kanu Priya","doi":"10.1016/j.cap.2025.01.015","DOIUrl":null,"url":null,"abstract":"<div><div>This research article explains a green synthesis of α-Fe₂O₃ nanoparticles (NPs) utilizing <em>Cedrus deodara</em> wood extract. The wood extract of this medicinal plant was used to synthesize the α-Fe₂O₃ NPs and utilized in various applications including biological applications on Osteosarcoma (MG63) and Lung cancer (A549). Along with this, we have also estimated its anti-bacterial properties on <em>P. aeruginosa</em> bacterial strain. The α-Fe₂O₃ NPs showed high antioxidant activity with DPPH and FRAP values of 86.05 % and 86.04 %, outperforming the antioxidant capacity of <em>Cedrus deodara</em> extract alone (79.16 % and 71.09 %). In cytotoxicity tests, they effectively inhibited osteosarcoma (MG63) and lung carcinoma (A549) cell lines, showing greater cytotoxicity against MG63 cells (IC<sub>50</sub> of 19.86 μg/mL) than A549 cells (IC<sub>50</sub> of 24.66 μg/mL) after 24 h. They also displayed strong antibacterial activity. This work presents a novel biogenic α-Fe₂O₃ nanoparticle synthesized from <em>Cedrus deodara</em> extract, exhibiting exceptional antioxidant, cytotoxic, and antibacterial activities.</div></div>","PeriodicalId":11037,"journal":{"name":"Current Applied Physics","volume":"72 ","pages":"Pages 1-10"},"PeriodicalIF":2.4000,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Sustainable synthesis of magnetic nanoparticles: Biological applications of Cedrus deodara extract\",\"authors\":\"Shilpa Kumari , Mohit Sahni , Soumya Pandit , Neha Verma , Firdaus Mohamad Hamzah , Kuldeep Sharma , Kanu Priya\",\"doi\":\"10.1016/j.cap.2025.01.015\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>This research article explains a green synthesis of α-Fe₂O₃ nanoparticles (NPs) utilizing <em>Cedrus deodara</em> wood extract. The wood extract of this medicinal plant was used to synthesize the α-Fe₂O₃ NPs and utilized in various applications including biological applications on Osteosarcoma (MG63) and Lung cancer (A549). Along with this, we have also estimated its anti-bacterial properties on <em>P. aeruginosa</em> bacterial strain. The α-Fe₂O₃ NPs showed high antioxidant activity with DPPH and FRAP values of 86.05 % and 86.04 %, outperforming the antioxidant capacity of <em>Cedrus deodara</em> extract alone (79.16 % and 71.09 %). In cytotoxicity tests, they effectively inhibited osteosarcoma (MG63) and lung carcinoma (A549) cell lines, showing greater cytotoxicity against MG63 cells (IC<sub>50</sub> of 19.86 μg/mL) than A549 cells (IC<sub>50</sub> of 24.66 μg/mL) after 24 h. They also displayed strong antibacterial activity. This work presents a novel biogenic α-Fe₂O₃ nanoparticle synthesized from <em>Cedrus deodara</em> extract, exhibiting exceptional antioxidant, cytotoxic, and antibacterial activities.</div></div>\",\"PeriodicalId\":11037,\"journal\":{\"name\":\"Current Applied Physics\",\"volume\":\"72 \",\"pages\":\"Pages 1-10\"},\"PeriodicalIF\":2.4000,\"publicationDate\":\"2025-01-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current Applied Physics\",\"FirstCategoryId\":\"101\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1567173925000161\",\"RegionNum\":4,\"RegionCategory\":\"物理与天体物理\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"MATERIALS SCIENCE, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Applied Physics","FirstCategoryId":"101","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1567173925000161","RegionNum":4,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

摘要

利用雪松木提取物绿色合成α-Fe₂O₃纳米粒子（NPs）。该药用植物的木材提取物被用来合成α-Fe₂O₃NPs，并用于各种应用，包括骨肉瘤（MG63）和肺癌（A549）的生物应用。同时，我们还对其对铜绿假单胞菌的抑菌性能进行了评价。α-Fe₂O₃NPs具有较高的抗氧化活性，DPPH和FRAP分别为86.05%和86.04%，优于雪松提取物的抗氧化能力（分别为79.16%和71.09%）。在细胞毒性实验中，它们对骨肉瘤（MG63）和肺癌（A549）细胞均有抑制作用，作用24 h后对MG63细胞的IC50值为19.86 μg/mL，比A549细胞的IC50值为24.66 μg/mL要高，并表现出较强的抗菌活性。本研究提出了一种新的生物源α-Fe₂O₃纳米颗粒，它是由雪松提取物合成的，具有优异的抗氧化、细胞毒和抗菌活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Sustainable synthesis of magnetic nanoparticles: Biological applications of Cedrus deodara extract

查看原文本刊更多论文

Sustainable synthesis of magnetic nanoparticles: Biological applications of Cedrus deodara extract

This research article explains a green synthesis of α-Fe₂O₃ nanoparticles (NPs) utilizing Cedrus deodara wood extract. The wood extract of this medicinal plant was used to synthesize the α-Fe₂O₃ NPs and utilized in various applications including biological applications on Osteosarcoma (MG63) and Lung cancer (A549). Along with this, we have also estimated its anti-bacterial properties on P. aeruginosa bacterial strain. The α-Fe₂O₃ NPs showed high antioxidant activity with DPPH and FRAP values of 86.05 % and 86.04 %, outperforming the antioxidant capacity of Cedrus deodara extract alone (79.16 % and 71.09 %). In cytotoxicity tests, they effectively inhibited osteosarcoma (MG63) and lung carcinoma (A549) cell lines, showing greater cytotoxicity against MG63 cells (IC₅₀ of 19.86 μg/mL) than A549 cells (IC₅₀ of 24.66 μg/mL) after 24 h. They also displayed strong antibacterial activity. This work presents a novel biogenic α-Fe₂O₃ nanoparticle synthesized from Cedrus deodara extract, exhibiting exceptional antioxidant, cytotoxic, and antibacterial activities.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Current Applied Physics 物理-材料科学：综合

CiteScore

4.80

自引率

0.00%

发文量

213

审稿时长

33 days

期刊介绍： Current Applied Physics (Curr. Appl. Phys.) is a monthly published international journal covering all the fields of applied science investigating the physics of the advanced materials for future applications. Other areas covered: Experimental and theoretical aspects of advanced materials and devices dealing with synthesis or structural chemistry, physical and electronic properties, photonics, engineering applications, and uniquely pertinent measurement or analytical techniques. Current Applied Physics, published since 2001, covers physics, chemistry and materials science, including bio-materials, with their engineering aspects. It is a truly interdisciplinary journal opening a forum for scientists of all related fields, a unique point of the journal discriminating it from other worldwide and/or Pacific Rim applied physics journals. Regular research papers, letters and review articles with contents meeting the scope of the journal will be considered for publication after peer review. The Journal is owned by the Korean Physical Society.