化学选择性脱氟胺化使（三氟甲基）烯烃与硫脲轻度[3 + 3]环化：6-氟-3,4-二氢嘧啶-2(1H)-硫酮的合成

IF 3.6 2区化学 Q1 CHEMISTRY, ORGANIC

Journal of Organic Chemistry Pub Date : 2025-01-21 DOI:10.1021/acs.joc.4c0247910.1021/acs.joc.4c02479

Rongbin Peng, and , Chuanle Zhu*,

引用次数: 0

摘要

报道了（三氟甲基）烯烃与硫脲的化学选择性脱氟[3 + 3]环。该方案以高产率提供各种有吸引力的6-氟-3,4-二氢嘧啶-2(1H)-硫酮，无过渡金属，条件温和，高效，操作简单，可扩展，可容纳各种有用的官能团。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Mild [3 + 3] Annulation of (Trifluoromethyl)alkenes with Thioureas Enabled by Chemoselective Defluorinative Amination: Synthesis of 6-Fluoro-3,4-dihydropyrimidine-2(1H)-thiones

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Mild [3 + 3] Annulation of (Trifluoromethyl)alkenes with Thioureas Enabled by Chemoselective Defluorinative Amination: Synthesis of 6-Fluoro-3,4-dihydropyrimidine-2(1H)-thiones

The chemoselective defluorinative [3 + 3] annulation of (trifluoromethyl)alkenes with thioureas is reported. This protocol affords various attractive 6-fluoro-3,4-dihydropyrimidine-2(1H)-thiones in high yields, features transition-metal free, mild conditions, efficient, is operationally simple and gram-scalable, tolerates diverse useful functional groups.

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来源期刊

Journal of Organic Chemistry 化学-有机化学

CiteScore

6.20

自引率

11.10%

发文量

1467

审稿时长

2 months

期刊介绍： Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.