磺胺电氧化s -亚胺肟化：一种无金属/催化剂的绿色方法

IF 7.3 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

ACS Sustainable Chemistry & Engineering Pub Date : 2025-01-15 DOI:10.1021/acssuschemeng.4c0887110.1021/acssuschemeng.4c08871

Padma Priya V. R., Sugapriya S., Antony Haritha Mercy A., Natarajan K., Ramesh Kataria and Ganesh Chandra Nandi*,

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引用次数: 0

摘要

在此，我们提出了一种无金属/催化剂的磺胺胺s -亚胺肟化的新方法。亚砜胺和亚砜亚胺的电氧化反应速度快，产率高，原子经济性（99.5%），耐宽底物，不需要辅助电解质。该方案是生态友好的，比以前的报告显示更广泛的底物耐受性。药物附著的磺胺（左乙拉西坦）和亚砜亚胺（阿苯达唑）也能有效地进行反应。提出了一种可能的机制途径。令人着迷的是，目标产物也是通过光催化剂伊红Y存在的光化学方法获得的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Electrooxidative S-Sulfoximination of Sulfenamide: A Metal-/Catalyst-Free Green Approach

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Electrooxidative S-Sulfoximination of Sulfenamide: A Metal-/Catalyst-Free Green Approach

Herein, we present a metal-/catalyst-free, novel approach for S-sulfoximination of sulfenamide. The electrooxidative reactions of sulfenamides and sulfoximines are fast, high-yielding, atom-economical (99.5%), broad-substrate-tolerant, and free from supporting electrolytes. The protocol is ecofriendly and shows wider substrate tolerance than previous reports. The drug-attached sulfenamide (levetiracetam) and sulfoximine (albendazole) also undergo the reaction efficiently. A possible mechanistic pathway is proposed. Fascinatingly, the target products are also obtained via a photochemical approach in the presence of photocatalyst eosin Y.

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来源期刊

ACS Sustainable Chemistry & Engineering CHEMISTRY, MULTIDISCIPLINARY-ENGINEERING, CHEMICAL

CiteScore

13.80

自引率

4.80%

发文量

1470

审稿时长

1.7 months

期刊介绍： ACS Sustainable Chemistry & Engineering is a prestigious weekly peer-reviewed scientific journal published by the American Chemical Society. Dedicated to advancing the principles of green chemistry and green engineering, it covers a wide array of research topics including green chemistry, green engineering, biomass, alternative energy, and life cycle assessment. The journal welcomes submissions in various formats, including Letters, Articles, Features, and Perspectives (Reviews), that address the challenges of sustainability in the chemical enterprise and contribute to the advancement of sustainable practices. Join us in shaping the future of sustainable chemistry and engineering.