Wei Cheng, Ying Wu, Bowen Li, Lichao Su, Min Wu, Luntao Liu, Shuhan Wang, Chunhua Lu* and Bin Liu*,
{"title":"用于气体治疗和表面等离子体共振增强光疗的肿瘤特异性原位合成硫化铜的一般策略","authors":"Wei Cheng, Ying Wu, Bowen Li, Lichao Su, Min Wu, Luntao Liu, Shuhan Wang, Chunhua Lu* and Bin Liu*, ","doi":"10.1021/acsmaterialslett.4c0180310.1021/acsmaterialslett.4c01803","DOIUrl":null,"url":null,"abstract":"<p >CuS nanomaterials have attracted much attention for tumor therapy because of their excellent photothermal and photodynamic properties. Notably, Cu<sub>2</sub>O can be converted in situ to CuS through sulfurization by H<sub>2</sub>S in tumor cells. However, this approach is currently limited to colon cancer because other tumors exhibit comparatively lower H<sub>2</sub>S concentrations. Herein, we reported a nanoplatform consisting of two key components, diallyl trisulfide (DATS) and Cu<sub>2</sub>O-coated nanogapped gold nanoparticle (AuNNP). DATS reacted with upregulated glutathione (GSH) in tumor cells to release H<sub>2</sub>S for gas therapy as well as the sulfurization of Cu<sub>2</sub>O. AuNNPs further enhanced the photothermal and photodynamic effect of the in situ-formed CuS via surface plasmon resonance effect. Both H<sub>2</sub>S-induced gas therapy and CuS-mediated photothermal/photodynamic therapy exhibited much higher toxicity to tumor cells than to normal cells. Given that GSH is typically overexpressed in cancer cells, the developed strategy is thus generally applicable for almost any tumors.</p>","PeriodicalId":19,"journal":{"name":"ACS Materials Letters","volume":"7 1","pages":"181–192 181–192"},"PeriodicalIF":8.7000,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A General Strategy for Tumor-Specific In Situ Synthesis of Copper Sulfide for Gas Therapy and Surface Plasmon Resonance Enhanced Phototherapy\",\"authors\":\"Wei Cheng, Ying Wu, Bowen Li, Lichao Su, Min Wu, Luntao Liu, Shuhan Wang, Chunhua Lu* and Bin Liu*, \",\"doi\":\"10.1021/acsmaterialslett.4c0180310.1021/acsmaterialslett.4c01803\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p >CuS nanomaterials have attracted much attention for tumor therapy because of their excellent photothermal and photodynamic properties. Notably, Cu<sub>2</sub>O can be converted in situ to CuS through sulfurization by H<sub>2</sub>S in tumor cells. However, this approach is currently limited to colon cancer because other tumors exhibit comparatively lower H<sub>2</sub>S concentrations. Herein, we reported a nanoplatform consisting of two key components, diallyl trisulfide (DATS) and Cu<sub>2</sub>O-coated nanogapped gold nanoparticle (AuNNP). DATS reacted with upregulated glutathione (GSH) in tumor cells to release H<sub>2</sub>S for gas therapy as well as the sulfurization of Cu<sub>2</sub>O. AuNNPs further enhanced the photothermal and photodynamic effect of the in situ-formed CuS via surface plasmon resonance effect. Both H<sub>2</sub>S-induced gas therapy and CuS-mediated photothermal/photodynamic therapy exhibited much higher toxicity to tumor cells than to normal cells. Given that GSH is typically overexpressed in cancer cells, the developed strategy is thus generally applicable for almost any tumors.</p>\",\"PeriodicalId\":19,\"journal\":{\"name\":\"ACS Materials Letters\",\"volume\":\"7 1\",\"pages\":\"181–192 181–192\"},\"PeriodicalIF\":8.7000,\"publicationDate\":\"2024-12-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACS Materials Letters\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://pubs.acs.org/doi/10.1021/acsmaterialslett.4c01803\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"MATERIALS SCIENCE, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Materials Letters","FirstCategoryId":"92","ListUrlMain":"https://pubs.acs.org/doi/10.1021/acsmaterialslett.4c01803","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
A General Strategy for Tumor-Specific In Situ Synthesis of Copper Sulfide for Gas Therapy and Surface Plasmon Resonance Enhanced Phototherapy
CuS nanomaterials have attracted much attention for tumor therapy because of their excellent photothermal and photodynamic properties. Notably, Cu2O can be converted in situ to CuS through sulfurization by H2S in tumor cells. However, this approach is currently limited to colon cancer because other tumors exhibit comparatively lower H2S concentrations. Herein, we reported a nanoplatform consisting of two key components, diallyl trisulfide (DATS) and Cu2O-coated nanogapped gold nanoparticle (AuNNP). DATS reacted with upregulated glutathione (GSH) in tumor cells to release H2S for gas therapy as well as the sulfurization of Cu2O. AuNNPs further enhanced the photothermal and photodynamic effect of the in situ-formed CuS via surface plasmon resonance effect. Both H2S-induced gas therapy and CuS-mediated photothermal/photodynamic therapy exhibited much higher toxicity to tumor cells than to normal cells. Given that GSH is typically overexpressed in cancer cells, the developed strategy is thus generally applicable for almost any tumors.
期刊介绍：
ACS Materials Letters is a journal that publishes high-quality and urgent papers at the forefront of fundamental and applied research in the field of materials science. It aims to bridge the gap between materials and other disciplines such as chemistry, engineering, and biology. The journal encourages multidisciplinary and innovative research that addresses global challenges. Papers submitted to ACS Materials Letters should clearly demonstrate the need for rapid disclosure of key results. The journal is interested in various areas including the design, synthesis, characterization, and evaluation of emerging materials, understanding the relationships between structure, property, and performance, as well as developing materials for applications in energy, environment, biomedical, electronics, and catalysis. The journal has a 2-year impact factor of 11.4 and is dedicated to publishing transformative materials research with fast processing times. The editors and staff of ACS Materials Letters actively participate in major scientific conferences and engage closely with readers and authors. The journal also maintains an active presence on social media to provide authors with greater visibility.
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