通过FMD促进TNBC的化疗加速代谢破坏

IF 27.7 1区生物学 Q1 CELL BIOLOGY

Cell metabolism Pub Date : 2025-02-04 DOI:10.1016/j.cmet.2024.12.015

Marcus D. Goncalves, Neil M. Iyengar

引用次数: 0

摘要

三阴性乳腺癌（TNBC）是高度糖酵解的，缺乏有效的治疗反应生物标志物。BREAKFAST试验显示，与历史化疗平均水平（30%-40%）相比，模拟禁食饮食（FMD）将病理完全缓解（pCR）率提高至56.6%，严重不良事件最少。口蹄疫的代谢和免疫调节作用值得进一步的免疫治疗研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Fueling metabolic disruption via FMD to boost chemotherapy in TNBC

Triple-negative breast cancer (TNBC) is highly glycolytic and lacks effective biomarkers for therapy response. The BREAKFAST trial showed that a fasting-mimicking diet (FMD) improved pathological complete response (pCR) rates to 56.6% compared to historical chemotherapy averages (30%–40%), with minimal severe adverse events. FMD’s metabolic and immune-modulating effects warrant further study with immunotherapy.

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来源期刊

Cell metabolism 生物-内分泌学与代谢

CiteScore

48.60

自引率

1.40%

发文量

173

审稿时长

2.5 months

期刊介绍： Cell Metabolism is a top research journal established in 2005 that focuses on publishing original and impactful papers in the field of metabolic research.It covers a wide range of topics including diabetes, obesity, cardiovascular biology, aging and stress responses, circadian biology, and many others. Cell Metabolism aims to contribute to the advancement of metabolic research by providing a platform for the publication and dissemination of high-quality research and thought-provoking articles.