用于探测组氨酸修饰的化学工具

IF 4.2 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemical Communications Pub Date : 2025-01-23 DOI:10.1039/d4cc06586g

Nurgül Bilgin , Jordi C. J. Hintzen , Jasmin Mecinović

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引用次数: 0

摘要

组氨酸是一种独特的氨基酸，在蛋白质结构和功能中起着至关重要的作用，从金属离子结合到酶催化。蛋白质中的组氨酸残基也经过各种酶的翻译后修饰，包括甲基化、磷酸化和羟基化，其中一些是最近才被发现和表征的。在这篇专题文章中，我们描述了用于理解组氨酸残基在化学和生物系统中的作用的化学工具的发展。我们重点介绍了组氨酸类似物在探索蛋白质中组氨酸残基翻译后修饰的应用，并重点介绍了新的生物偶联方法，使组氨酸残基在肽和蛋白质中的化学选择性修饰成为可能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Chemical tools for probing histidine modifications

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Chemical tools for probing histidine modifications

Histidine is a unique amino acid with critical roles in protein structure and function, ranging from metal ion binding to enzyme catalysis. Histidine residues in proteins also undergo diverse posttranslational modifications, including methylation, phosphorylation and hydroxylation, by various enzymes, some of them being only recently identified and characterised. In this review, we describe the development of chemical tools for understanding the role of histidine residues in chemical and biological systems. We spotlight the application of histidine analogues in probing biomedically important posttranslational modifications of histidine residues in proteins, and we highlight novel bioconjugation methods that enable chemoselective modifications of histidine residues in peptides and proteins.

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来源期刊

Chemical Communications 化学-化学综合

CiteScore

8.60

自引率

4.10%

发文量

2705

审稿时长

1.4 months

期刊介绍： ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.