MhOR1作为气味剂介导胰岛素释放的化学发生工具的研究进展

IF 4.2 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemical Communications Pub Date : 2025-02-04 DOI:10.1039/D5CC00304K

Hanbing Li, Gaojun Chen, Xiayan Lou, Changyi Hu, Ninghuai Zheng, Lian He and Yuanfa Yao

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引用次数: 0

摘要

我们的研究提出了MhOR1，一种气味反应的化学发生工具，在气味激活时促进钙的流入。我们优化了它的膜表达，并证明了它在胰腺β细胞中调节胰岛素释放的能力。我们的研究结果表明，MhOR1具有通过气味触发的细胞活动进行基因调控和治疗应用的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Development of MhOR1 as a chemogenetic tool for odorant-mediated regulation of insulin release†

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Development of MhOR1 as a chemogenetic tool for odorant-mediated regulation of insulin release†

Our study presents MhOR1, an odorant-responsive chemogenetic tool that facilitates calcium influx upon odorant activation. We optimized its membrane expression and demonstrated its ability to regulate insulin release in pancreatic β cells. Our results suggest that MhOR1 holds potential for gene regulation and therapeutic applications through odorant-triggered cellular activities.

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来源期刊

Chemical Communications 化学-化学综合

CiteScore

8.60

自引率

4.10%

发文量

2705

审稿时长

1.4 months

期刊介绍： ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.