Exploring Zika's dynamics: A scoping review journey from epidemic to equations through mathematical modelling

Zika virus (ZIKV) infection, along with the concurrent circulation of other arboviruses, presents a great public health challenge, reminding the utilization of mathematical modelling as a crucial tool for explaining its intricate dynamics and interactions with co-circulating pathogens. Through a scoping review, we aimed to discern current mathematical models investigating ZIKV dynamics, focusing on its interplay with other pathogens, and to identify underlying assumptions and deficiencies supporting attention, particularly regarding the epidemiological attributes characterizing Zika outbreaks. Following the PRISMA-Sc guidelines, a systematic search across PubMed, Web of Science, and MathSciNet provided 137 pertinent studies from an initial pool of 2446 papers, showing a diversity of modelling approaches, predominantly centered on vector-host compartmental models, with a notable concentration on the epidemiological landscapes of Colombia and Brazil during the 2015–2016 Zika epidemic. While modelling studies have been important in explaining Zika transmission dynamics and their intersections with diseases such as Dengue, Chikungunya, and COVID-19 so far, future Zika models should prioritize robust data integration and rigorous validation against diverse datasets to improve the accuracy and reliability of epidemic prediction. In addition, models could benefit from adaptable frameworks incorporating human behavior, environmental factors, and stochastic parameters, with an emphasis on open-access tools to foster transparency and research collaboration.