Anne E Sanders, Jianwen Cai, Martha L Daviglus, Olga Garcia-Bedoya, Gary D Slade
{"title":"西班牙裔社区健康研究/拉丁裔研究中的长链多不饱和脂肪酸和疼痛性颞下颌疾病","authors":"Anne E Sanders, Jianwen Cai, Martha L Daviglus, Olga Garcia-Bedoya, Gary D Slade","doi":"10.1017/S1368980025000102","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong><i>n</i>-6 and <i>n</i>-3 long-chain PUFA play opposing roles in inflammation, anxiety and nociception, all of which are closely associated with chronic pain. We hypothesised that diets high in <i>n</i>-6 arachidonic acid (C20:4<i>n</i>-6, AA) and low in combined <i>n</i>-3 EPA (C20:5<i>n</i>-3, EPA) and DHA (C22:6<i>n</i>-3, DHA) would be associated with higher odds of painful temporomandibular disorder (TMD).</p><p><strong>Design: </strong>We analysed baseline data from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). Two 24-h dietary recall surveys quantified intake of long-chain <i>n</i>-6 and <i>n</i>-3 PUFA along with their precursors, linoleic acid (C18:2<i>n</i>-6, LA) and alpha linolenic acid (C18:3<i>n</i>-3, ALA), respectively. <i>n</i>-3 PUFA supplementation was quantified. Interviewer-administered questions assessed TMD. Survey multiple logistic regression estimated covariate-adjusted OR and 95 % confidence limits (CL) for associations between PUFA and TMD.</p><p><strong>Setting: </strong>From 2008 to 2011, HCHS/SOL recruited 16 415 adults of Hispanic/Latino backgrounds (Cuban, Puerto Rican, Dominican, Mexican, Central/South American), through field centres located in Miami, FL; San Diego CA; Chicago, IL; and the Bronx, NY.</p><p><strong>Participants: </strong>13 870 participants with non-missing data.</p><p><strong>Results: </strong>In analysis adjusted for covariates, each sd increase in dietary intake of C20:4<i>n</i>-6, AA was associated with 12 % higher odds of TMD (OR = 1·12, CL: 1·01, 1·24). Although the dietary intake of combined long-chain C20:5<i>n</i>-3, EPA and C22:6<i>n</i>-3 DHA was not associated with TMD, each sd increase in <i>n</i>-3 dietary supplement was associated with lower odds of TMD.</p><p><strong>Conclusions: </strong>A diet rich in C20:4<i>n</i>-6, AA was associated with higher odds of painful TMD.</p>","PeriodicalId":20951,"journal":{"name":"Public Health Nutrition","volume":" ","pages":"e41"},"PeriodicalIF":3.0000,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11883565/pdf/","citationCount":"0","resultStr":"{\"title\":\"Long-chain PUFA and painful temporomandibular disorder in the Hispanic Community Health Study/Study of Latinos.\",\"authors\":\"Anne E Sanders, Jianwen Cai, Martha L Daviglus, Olga Garcia-Bedoya, Gary D Slade\",\"doi\":\"10.1017/S1368980025000102\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong><i>n</i>-6 and <i>n</i>-3 long-chain PUFA play opposing roles in inflammation, anxiety and nociception, all of which are closely associated with chronic pain. We hypothesised that diets high in <i>n</i>-6 arachidonic acid (C20:4<i>n</i>-6, AA) and low in combined <i>n</i>-3 EPA (C20:5<i>n</i>-3, EPA) and DHA (C22:6<i>n</i>-3, DHA) would be associated with higher odds of painful temporomandibular disorder (TMD).</p><p><strong>Design: </strong>We analysed baseline data from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). Two 24-h dietary recall surveys quantified intake of long-chain <i>n</i>-6 and <i>n</i>-3 PUFA along with their precursors, linoleic acid (C18:2<i>n</i>-6, LA) and alpha linolenic acid (C18:3<i>n</i>-3, ALA), respectively. <i>n</i>-3 PUFA supplementation was quantified. Interviewer-administered questions assessed TMD. Survey multiple logistic regression estimated covariate-adjusted OR and 95 % confidence limits (CL) for associations between PUFA and TMD.</p><p><strong>Setting: </strong>From 2008 to 2011, HCHS/SOL recruited 16 415 adults of Hispanic/Latino backgrounds (Cuban, Puerto Rican, Dominican, Mexican, Central/South American), through field centres located in Miami, FL; San Diego CA; Chicago, IL; and the Bronx, NY.</p><p><strong>Participants: </strong>13 870 participants with non-missing data.</p><p><strong>Results: </strong>In analysis adjusted for covariates, each sd increase in dietary intake of C20:4<i>n</i>-6, AA was associated with 12 % higher odds of TMD (OR = 1·12, CL: 1·01, 1·24). Although the dietary intake of combined long-chain C20:5<i>n</i>-3, EPA and C22:6<i>n</i>-3 DHA was not associated with TMD, each sd increase in <i>n</i>-3 dietary supplement was associated with lower odds of TMD.</p><p><strong>Conclusions: </strong>A diet rich in C20:4<i>n</i>-6, AA was associated with higher odds of painful TMD.</p>\",\"PeriodicalId\":20951,\"journal\":{\"name\":\"Public Health Nutrition\",\"volume\":\" \",\"pages\":\"e41\"},\"PeriodicalIF\":3.0000,\"publicationDate\":\"2025-02-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11883565/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Public Health Nutrition\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1017/S1368980025000102\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"NUTRITION & DIETETICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Public Health Nutrition","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1017/S1368980025000102","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}
Long-chain PUFA and painful temporomandibular disorder in the Hispanic Community Health Study/Study of Latinos.
Objective: n-6 and n-3 long-chain PUFA play opposing roles in inflammation, anxiety and nociception, all of which are closely associated with chronic pain. We hypothesised that diets high in n-6 arachidonic acid (C20:4n-6, AA) and low in combined n-3 EPA (C20:5n-3, EPA) and DHA (C22:6n-3, DHA) would be associated with higher odds of painful temporomandibular disorder (TMD).
Design: We analysed baseline data from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). Two 24-h dietary recall surveys quantified intake of long-chain n-6 and n-3 PUFA along with their precursors, linoleic acid (C18:2n-6, LA) and alpha linolenic acid (C18:3n-3, ALA), respectively. n-3 PUFA supplementation was quantified. Interviewer-administered questions assessed TMD. Survey multiple logistic regression estimated covariate-adjusted OR and 95 % confidence limits (CL) for associations between PUFA and TMD.
Setting: From 2008 to 2011, HCHS/SOL recruited 16 415 adults of Hispanic/Latino backgrounds (Cuban, Puerto Rican, Dominican, Mexican, Central/South American), through field centres located in Miami, FL; San Diego CA; Chicago, IL; and the Bronx, NY.
Participants: 13 870 participants with non-missing data.
Results: In analysis adjusted for covariates, each sd increase in dietary intake of C20:4n-6, AA was associated with 12 % higher odds of TMD (OR = 1·12, CL: 1·01, 1·24). Although the dietary intake of combined long-chain C20:5n-3, EPA and C22:6n-3 DHA was not associated with TMD, each sd increase in n-3 dietary supplement was associated with lower odds of TMD.
Conclusions: A diet rich in C20:4n-6, AA was associated with higher odds of painful TMD.
期刊介绍：
Public Health Nutrition provides an international peer-reviewed forum for the publication and dissemination of research and scholarship aimed at understanding the causes of, and approaches and solutions to nutrition-related public health achievements, situations and problems around the world. The journal publishes original and commissioned articles, commentaries and discussion papers for debate. The journal is of interest to epidemiologists and health promotion specialists interested in the role of nutrition in disease prevention; academics and those involved in fieldwork and the application of research to identify practical solutions to important public health problems.
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