轻度认知障碍患者内侧前额叶皮层微结构异常与白质高信号的相关性研究：弥散峰度成像研究。

IF 2.1 4区医学 Q3 CLINICAL NEUROLOGY

Psychiatry Research: Neuroimaging Pub Date : 2025-01-31 DOI:10.1016/j.pscychresns.2025.111958

Dongtao Liu , Xiangke Ma , Xinhui Li , Kun Li , Qiao Bu , Lichun Zhou

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引用次数: 0

摘要

背景：本研究旨在通过弥散峰度成像（DKI）研究轻度认知障碍（MCI）患者内侧前额叶皮层（m-PFC）微结构变化与白质高信号（WMHs）的相关性。方法：我们回顾性收集了68例患者，其中47例wmh患者和21例年龄匹配的对照组。wmh患者分为有MCI组（n = 30）和无MCI组（n = 17）。对利益区域（roi）选择m-PFC。测定各组间DKI参数并进行比较。DKI参数与蒙特利尔认知评估（MoCA）评分之间也存在相关性。结果:1。与对照组相比，wmh患者MoCA评分较低；wmh合并MCI患者m-PFC右前扣带和副扣带回（ACG）具有显著的低轴向峰度（AK）、平均峰度（MK）、径向峰度（RK）和分数各向异性（FA）；左ACG的MK也明显降低。2. 与无MCI患者的wmh相比，MCI患者的AK、FA和峰度分数各向异性（KFA）也显著降低。3. 在两个ACG中，AK与MoCA评分呈正相关。结论：wmh患者与MCI相关。DKI序列对评价重度脑损伤患者是否存在认知功能障碍具有一定的应用价值。

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Correlation study between the microstructural abnormalities of medial prefrontal cortex and white matter hyperintensities with mild cognitive impairment patients: A diffusion kurtosis imaging study

Background

Our study aimed to investigate the correlation between the microstructural changes of medial prefrontal cortex (m-PFC) and white matter hyperintensities (WMHs) with mild cognitive impairment (MCI) patients by Diffusion kurtosis imaging (DKI).

Methods

We retrospectively collected 68 patients, including 47 patients with WMHs and 21 age matched controls. WMHs patients were divided into with MCI (n = 30) and without MCI group (n = 17). The m-PFC was selected for regions of interests (ROIs). DKI parameters were measured and compared between each group. Correlations between DKI parameters and Montreal cognitive assessment (MoCA) score were also performed.

Results

1. Compared to controls, WMHs patients have lower MoCA score; WMHs with MCI patients have significant lower axial kurtosis (AK), mean kurtosis (MK), radial kurtosis (RK) and fractional anisotropy (FA) in right anterior cingulate and paracingulate gyri (ACG) of m-PFC; and also have significant lower MK in left ACG. 2. Compared to WMHs without MCI patients, AK, FA and kurtosis fractional anisotropy (KFA) of WMHs with MCI patients were also significantly decreased. 3. AK were positively correlated with MoCA score in both ACG.

Conclusions

Patients with WMHs were related to MCI. DKI sequence has certain application value in evaluating whether WMHs with MCI patients have cognitive function impaired.

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来源期刊

Psychiatry Research: Neuroimaging 医学-精神病学

CiteScore

3.80

自引率

0.00%

发文量

审稿时长

22.5 weeks

期刊介绍： The Neuroimaging section of Psychiatry Research publishes manuscripts on positron emission tomography, magnetic resonance imaging, computerized electroencephalographic topography, regional cerebral blood flow, computed tomography, magnetoencephalography, autoradiography, post-mortem regional analyses, and other imaging techniques. Reports concerning results in psychiatric disorders, dementias, and the effects of behaviorial tasks and pharmacological treatments are featured. We also invite manuscripts on the methods of obtaining images and computer processing of the images themselves. Selected case reports are also published.