8周Theracurmin Super （TS-P1）的疗效；姜黄素补充对运动诱导的氧化应激：一项随机、双盲、安慰剂对照的平行临床试验。

IF 2.8 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Integrative Medicine Research Pub Date : 2024-11-15 DOI:10.1016/j.imr.2024.101099

Xinxing Li , Dae Young Kim , Yunho Sung , Donghyun Kim , Seohyun Ahn , Hyejung Shin , Nur Afiqah Binti Zulkifli , Ji-won Seo , Shu Jiang , Parivash Jamrasi , SoYoung Ahn , Jun Hyun Bae , HeeKyung Yeo , Hayoung Park , Wook Song

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引用次数: 0

摘要

背景：鉴于姜黄素的抗氧化特性，本研究旨在确定Theracurmin Super补充剂在健康成人中减轻运动诱导的氧化应激的有效性和安全性。方法：于2022年4月至2023年3月在首尔国立大学对71名健康成人进行了研究。在第一次访问期间，通过使用布鲁斯跑步机方案评估最大耗氧量来确定患者的资格。在第2次访问中，参与者被随机分配到Theracurmin超级补充剂组（TG, n = 36）或安慰剂补充剂组（PG, n = 35）。在8周的时间里，参与者每天服用两次Theracurmin Super（姜黄素，120毫克/天）或安慰剂（姜黄素，0毫克/天），并访问实验室四次。在每次访问时评估各种参数，包括身体组成、生命体征、成人营养商数、心肺耐力、血液生物标志物和不良事件。统计分析包括协议分析、组内和组内差异的t检验和双向方差分析。结果：在第8周，与氧化应激相关的血液生物标志物，包括TBARs、MDA、8- ohdg、SOD、TOS和OSI，显示出显著的组和周相关相互作用(总氧化状态：静息状态P = 0.021；氧化应激指数，静息状态P = 0.020，运动结束P = 0.013)。值得注意的是，TG显示总氧化状态（静息状态P = 0.041）和氧化应激指数（静息状态P = 0.018，运动结束P = 0.008）在第0周至第8周之间显著下降。然而，MDA和8-OHdG水平没有统计学上的显著变化。结论：Theracurmin Super能有效降低运动前后的氧化应激，显示姜黄素在控制氧化应激中的重要作用。观察到TOS和OSI的显著改善，尽管MDA和8-OHdG水平的变化无统计学意义。进一步的研究可以深入了解这些不同氧化生物标志物的混合结果。试验注册：临床研究信息服务（CRIS）： KCT0008731。

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Effects of 8-week Theracurmin Super (TS-P1; Curcumin) supplementation on exercise-induced oxidative stress: A randomised, double-blind, placebo-controlled parallel clinical trial

Background

Given curcumin's antioxidant properties, this study aimed to determine the effectiveness and safety of Theracurmin Super supplementation in mitigating exercise-induced oxidative stress in healthy adults.

Methods

Seventy-one healthy adults participated in this study, which was conducted at Seoul National University from April 2022 to March 2023. Eligibility was determined during visit 1 through maximum oxygen consumption assessed using the Bruce Treadmill protocol. In visit 2, participants were randomly allocated to either the Theracurmin Super supplement group (TG, n = 36) or Placebo supplement group (PG, n = 35). Over 8 weeks, participants consumed Theracurmin Super (curcumin, 120 mg/day) or Placebo (curcumin, 0 mg/day) twice daily and visited the laboratory four times. Various parameters, including body composition, vital signs, nutrition quotient for adults, cardiorespiratory endurance, blood biomarkers, and adverse events, were assessed at each visit. Statistical analyses included per-protocol analysis, t-tests for group and within-group differences, and two-way ANOVA.

Results

In week 8, blood biomarkers linked to oxidative stress, including TBARs, MDA, 8-OHdG, SOD, TOS, and OSI, showed significant group- and week-related interactions (total oxidant status: resting state P = 0.021; oxidative stress index, resting state P = 0.020, end of exercise, P = 0.013). Notably, the TG showed a significant decrease in total oxidant status (resting state P = 0.041) and oxidative stress index (resting state P = 0.018 and end of exercise P = 0.008) between weeks 0 and 8. However, MDA and 8-OHdG levels did not show statistically significant changes.

Conclusion

Theracurmin Super effectively reduced oxidative stress before and after exercise, highlighting curcumin's promising role in managing oxidative stress. Significant improvements in TOS and OSI were observed, although changes in MDA and 8-OHdG levels were not statistically significant. Further research could provide insights into these mixed results across different oxidative biomarkers.

Trial registration

Clinical Research Information Service (CRIS): KCT0008731.

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来源期刊

Integrative Medicine Research Medicine-Complementary and Alternative Medicine

CiteScore

6.50

自引率

2.90%

发文量

审稿时长

12 weeks

期刊介绍： Integrative Medicine Research (IMR) is a quarterly, peer-reviewed journal focused on scientific research for integrative medicine including traditional medicine (emphasis on acupuncture and herbal medicine), complementary and alternative medicine, and systems medicine. The journal includes papers on basic research, clinical research, methodology, theory, computational analysis and modelling, topical reviews, medical history, education and policy based on physiology, pathology, diagnosis and the systems approach in the field of integrative medicine.