真丝织物支架的体外和体内生物降解研究。

Q3 Agricultural and Biological Sciences

Doklady Biological Sciences Pub Date : 2025-02-01 Epub Date: 2025-01-31 DOI:10.1134/S0012496624600519

I I Agapov, E I Podbolotova, L A Kirsanova, N V Grudinin, A R Pashutin, O I Agapova, A E Efimov, A V Lyundup, S V Gautier

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引用次数: 0

摘要

在体外和体内研究了由纱布和缎子织物制成的天然丝支架的生物降解。实验采用磷酸盐缓冲盐水（PBS）和Fenton试剂模拟降解。样品在生理条件和氧化应激的不同降解率模型中表现出高稳定性。在大鼠体内的研究表明，支架具有良好的生物相容性，炎症反应逐渐减少。这一发现突出了丝支架在再生医学各个领域的应用潜力。

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In Vitro and In Vivo Biodegradation of Silk Fabric Scaffolds.

Biodegradation of natural silk scaffolds made from gauze and satin fabrics was studied both in vitro and in vivo. Experiments were conducted using phosphate-buffered saline (PBS) and Fenton's reagent to model degradation. Samples demonstrated high stability in the model of physiological conditions and varying degradation rates in oxidative stress. In vivo studies in rats showed good biocompatibility of the scaffolds and a gradual reduction in inflammatory responses. The findings highlight the potential of silk scaffolds for use in various areas of regenerative medicine.

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来源期刊

Doklady Biological Sciences Agricultural and Biological Sciences-Agricultural and Biological Sciences (all)

CiteScore

1.10

自引率

0.00%

发文量

期刊介绍： Doklady Biological Sciences is a journal that publishes new research in biological sciences of great significance. Initially the journal was a forum of the Russian Academy of Science and published only best contributions from Russia in the form of short articles. Now the journal welcomes submissions from any country in the English or Russian language. Every manuscript must be recommended by Russian or foreign members of the Russian Academy of Sciences.