Christos V Chalitsios, Georgios Markozannes, Christos Papagiannopoulos, Elom K Aglago, Sonja I Berndt, Daniel D Buchanan, Peter T Campbell, Yin Cao, Andrew T Chan, Niki Dimou, David A Drew, Amy J French, Peter Georgeson, Marios Giannakis, Stephen B Gruber, Marc J Gunter, Tabitha A Harrison, Michael Hoffmeister, Li Hsu, Wen-Yi Huang, Meredith A J Hullar, Jeroen R Huyghe, Brigid M Lynch, Victor Moreno, Christina C Newton, Jonathan A Nowak, Mireia Obón-Santacana, Shuji Ogino, Conghui Qu, Stephanie L Schmit, Robert S Steinfelder, Wei Sun, Claire E Thomas, Amanda E Toland, Quang M Trinh, Tomotaka Ugai, Caroline Y Um, Bethany Van Guelpen, Syed H Zaidi, Neil Murphy, Ulrike Peters, Amanda I Phipps, Konstantinos K Tsilidis
{"title":"腰围、体型指数和结直肠癌的分子亚型：四项队列研究的汇总分析","authors":"Christos V Chalitsios, Georgios Markozannes, Christos Papagiannopoulos, Elom K Aglago, Sonja I Berndt, Daniel D Buchanan, Peter T Campbell, Yin Cao, Andrew T Chan, Niki Dimou, David A Drew, Amy J French, Peter Georgeson, Marios Giannakis, Stephen B Gruber, Marc J Gunter, Tabitha A Harrison, Michael Hoffmeister, Li Hsu, Wen-Yi Huang, Meredith A J Hullar, Jeroen R Huyghe, Brigid M Lynch, Victor Moreno, Christina C Newton, Jonathan A Nowak, Mireia Obón-Santacana, Shuji Ogino, Conghui Qu, Stephanie L Schmit, Robert S Steinfelder, Wei Sun, Claire E Thomas, Amanda E Toland, Quang M Trinh, Tomotaka Ugai, Caroline Y Um, Bethany Van Guelpen, Syed H Zaidi, Neil Murphy, Ulrike Peters, Amanda I Phipps, Konstantinos K Tsilidis","doi":"10.1158/1055-9965.EPI-24-1534","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Waist circumference (WC) and its allometric counterpart, \"a body shape index\" (ABSI), are risk factors for colorectal cancer; however, it is uncertain whether associations with these body measurements are limited to specific molecular subtypes of the disease.</p><p><strong>Methods: </strong>Data from 2,772 colorectal cancer cases and 3,521 controls were pooled from four cohort studies within the Genetics and Epidemiology of Colorectal Cancer Consortium. Four molecular markers (BRAF mutation, KRAS mutation, CpG island methylator phenotype, and microsatellite instability) were analyzed individually and in combination (Jass types). Multivariable logistic and multinomial logistic models were used to assess the associations of WC and ABSI with overall colorectal cancer risk and, in case-only analyses, to evaluate heterogeneity by molecular subtype, respectively.</p><p><strong>Results: </strong>Higher WC (ORper 5 cm = 1.06, 95% confidence interval, 1.04-1.09) and ABSI (ORper 1-SD = 1.07, 95% confidence interval, 1.00-1.14) were associated with elevated colorectal cancer risk. There was no evidence of heterogeneity between the molecular subtypes. No difference was observed regarding the influence of WC and ABSI on the four major molecular markers in proximal colon, distal colon, and rectal cancers, as well as in early- and late-onset colorectal cancers. Associations did not differ in the Jass-type analysis.</p><p><strong>Conclusions: </strong>Higher WC and ABSI were associated with elevated colorectal cancer risk; however, they do not differentially influence all four major molecular mutations involved in colorectal carcinogenesis but underscore the importance of maintaining a healthy body weight in colorectal cancer prevention.</p><p><strong>Impact: </strong>The proposed results have potential utility in colorectal cancer prevention.</p>","PeriodicalId":9458,"journal":{"name":"Cancer Epidemiology Biomarkers & Prevention","volume":" ","pages":"568-577"},"PeriodicalIF":3.7000,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Waist Circumference, a Body Shape Index, and Molecular Subtypes of Colorectal Cancer: A Pooled Analysis of Four Cohort Studies.\",\"authors\":\"Christos V Chalitsios, Georgios Markozannes, Christos Papagiannopoulos, Elom K Aglago, Sonja I Berndt, Daniel D Buchanan, Peter T Campbell, Yin Cao, Andrew T Chan, Niki Dimou, David A Drew, Amy J French, Peter Georgeson, Marios Giannakis, Stephen B Gruber, Marc J Gunter, Tabitha A Harrison, Michael Hoffmeister, Li Hsu, Wen-Yi Huang, Meredith A J Hullar, Jeroen R Huyghe, Brigid M Lynch, Victor Moreno, Christina C Newton, Jonathan A Nowak, Mireia Obón-Santacana, Shuji Ogino, Conghui Qu, Stephanie L Schmit, Robert S Steinfelder, Wei Sun, Claire E Thomas, Amanda E Toland, Quang M Trinh, Tomotaka Ugai, Caroline Y Um, Bethany Van Guelpen, Syed H Zaidi, Neil Murphy, Ulrike Peters, Amanda I Phipps, Konstantinos K Tsilidis\",\"doi\":\"10.1158/1055-9965.EPI-24-1534\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Waist circumference (WC) and its allometric counterpart, \\\"a body shape index\\\" (ABSI), are risk factors for colorectal cancer; however, it is uncertain whether associations with these body measurements are limited to specific molecular subtypes of the disease.</p><p><strong>Methods: </strong>Data from 2,772 colorectal cancer cases and 3,521 controls were pooled from four cohort studies within the Genetics and Epidemiology of Colorectal Cancer Consortium. Four molecular markers (BRAF mutation, KRAS mutation, CpG island methylator phenotype, and microsatellite instability) were analyzed individually and in combination (Jass types). Multivariable logistic and multinomial logistic models were used to assess the associations of WC and ABSI with overall colorectal cancer risk and, in case-only analyses, to evaluate heterogeneity by molecular subtype, respectively.</p><p><strong>Results: </strong>Higher WC (ORper 5 cm = 1.06, 95% confidence interval, 1.04-1.09) and ABSI (ORper 1-SD = 1.07, 95% confidence interval, 1.00-1.14) were associated with elevated colorectal cancer risk. There was no evidence of heterogeneity between the molecular subtypes. No difference was observed regarding the influence of WC and ABSI on the four major molecular markers in proximal colon, distal colon, and rectal cancers, as well as in early- and late-onset colorectal cancers. 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Waist Circumference, a Body Shape Index, and Molecular Subtypes of Colorectal Cancer: A Pooled Analysis of Four Cohort Studies.
Background: Waist circumference (WC) and its allometric counterpart, "a body shape index" (ABSI), are risk factors for colorectal cancer; however, it is uncertain whether associations with these body measurements are limited to specific molecular subtypes of the disease.
Methods: Data from 2,772 colorectal cancer cases and 3,521 controls were pooled from four cohort studies within the Genetics and Epidemiology of Colorectal Cancer Consortium. Four molecular markers (BRAF mutation, KRAS mutation, CpG island methylator phenotype, and microsatellite instability) were analyzed individually and in combination (Jass types). Multivariable logistic and multinomial logistic models were used to assess the associations of WC and ABSI with overall colorectal cancer risk and, in case-only analyses, to evaluate heterogeneity by molecular subtype, respectively.
Results: Higher WC (ORper 5 cm = 1.06, 95% confidence interval, 1.04-1.09) and ABSI (ORper 1-SD = 1.07, 95% confidence interval, 1.00-1.14) were associated with elevated colorectal cancer risk. There was no evidence of heterogeneity between the molecular subtypes. No difference was observed regarding the influence of WC and ABSI on the four major molecular markers in proximal colon, distal colon, and rectal cancers, as well as in early- and late-onset colorectal cancers. Associations did not differ in the Jass-type analysis.
Conclusions: Higher WC and ABSI were associated with elevated colorectal cancer risk; however, they do not differentially influence all four major molecular mutations involved in colorectal carcinogenesis but underscore the importance of maintaining a healthy body weight in colorectal cancer prevention.
Impact: The proposed results have potential utility in colorectal cancer prevention.
期刊介绍：
Cancer Epidemiology, Biomarkers & Prevention publishes original peer-reviewed, population-based research on cancer etiology, prevention, surveillance, and survivorship. The following topics are of special interest: descriptive, analytical, and molecular epidemiology; biomarkers including assay development, validation, and application; chemoprevention and other types of prevention research in the context of descriptive and observational studies; the role of behavioral factors in cancer etiology and prevention; survivorship studies; risk factors; implementation science and cancer care delivery; and the science of cancer health disparities. Besides welcoming manuscripts that address individual subjects in any of the relevant disciplines, CEBP editors encourage the submission of manuscripts with a transdisciplinary approach.
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