葡萄膜皮肤病综合征,并发无菌性脑膜脑炎的狗。

IF 0.9 4区 农林科学 Q3 VETERINARY SCIENCES
Jessica P M Lam, Bernadett Rozsa, Mathieu Victor Paulin, Danica R Lucyshyn, Jasmine Gu, Brad Cotter, Bruce Grahn, Anthony Carr, Susan Taylor
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引用次数: 0

摘要

犬葡萄膜皮肤病综合征(UDS)类似于人类Vogt-Koyanagi-Harada综合征,但通常缺乏相关的神经症状。我们报告一只3岁的澳大利亚牧羊犬,在双侧摘除和组织病理学检查后被诊断为UDS。术后12天出现神经系统症状,包括头部倾斜、打转和耳聋。脑MRI和脑脊液分析与不明原因脑膜脑炎(MUE)一致。口服免疫抑制治疗(强的松和环孢素)显著改善。8个月后,在逐渐减少剂量期间,MUE复发,促使剂量增加到免疫抑制水平。4个月后,这只狗因无关原因死亡,促使对其进行尸检。本报告增加了与UDS相关的犬MUE的有限文献,并强调了诊断和管理方面的挑战。文献回顾表明,这是第二例报道的犬vogt - koyanagi - harada样脑膜脑炎病例,也是第一例通过MRI和CSF分析确诊的病例。关键临床信息:将UDS作为MUE并发眼部和皮肤体征的鉴别诊断是很重要的。对于去核后经组织学诊断为UDS的狗,更积极的免疫抑制治疗或警惕监测神经症状可能有助于预防或减缓神经系统受损伤的进展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Uveodermatologic syndrome presenting with concurrent aseptic meningoencephalitis in a dog.

Canine uveodermatologic syndrome (UDS) resembles human Vogt-Koyanagi-Harada syndrome but typically lacks associated neurological signs. We report a 3-year-old Australian shepherd dog diagnosed with UDS following bilateral enucleation and histopathology. Twelve days postoperatively, neurological symptoms developed, including head tilt, circling, and deafness. Brain MRI and CSF analyses were consistent with meningoencephalitis of unknown etiology (MUE). Oral immunosuppressive therapy (prednisone and cyclosporine) resulted in substantial improvement. Eight months later, during gradual dose reduction, MUE relapsed, prompting an increase in dose to immunosuppressive levels. The dog's death due to an unrelated cause 4 mo later prompted postmortem evaluation. This report adds to the limited literature on MUE associated with UDS in dogs and underscores challenges in diagnosis and management. Literature review suggests this is the second reported case of Vogt-Koyanagi-Harada-like meningoencephalitis in a dog and the first reported case with a confirmed diagnosis via MRI and CSF analyses. Key clinical message: It is important to include UDS as a differential diagnosis for dogs that present with MUE with concurrent ocular and cutaneous signs. For dogs diagnosed with UDS on histology after enucleation, more aggressive immunosuppressive treatment or vigilant monitoring for neurological signs may help prevent or slow progression to neurological involvement.

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来源期刊
CiteScore
1.20
自引率
10.00%
发文量
177
审稿时长
12-24 weeks
期刊介绍: The Canadian Veterinary Journal (CVJ) provides a forum for the discussion of all matters relevant to the veterinary profession. The mission of the Journal is to educate by informing readers of progress in clinical veterinary medicine, clinical veterinary research, and related fields of endeavor. The key objective of The CVJ is to promote the art and science of veterinary medicine and the betterment of animal health. A report suggesting that animals have been unnecessarily subjected to adverse, stressful, or harsh conditions or treatments will not be processed for publication. Experimental studies using animals will only be considered for publication if the studies have been approved by an institutional animal care committee, or equivalent, and the guidelines of the Canadian Council on Animal Care, or equivalent, have been followed by the author(s).
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