Ashok K. Singh, Ravindra K. Singh, Kumud Pandav, Swaila Bano, Farha Arshi, Amarendra Kumar, Sudheer Kumar Singh, Ramesh Chandra
{"title":"新Ru(III) 2,6-双（2-苯并咪唑）吡啶配合物-对亚苄基硫代氨基脲希夫碱：合成、表征、DNA结合及抗癌活性","authors":"Ashok K. Singh, Ravindra K. Singh, Kumud Pandav, Swaila Bano, Farha Arshi, Amarendra Kumar, Sudheer Kumar Singh, Ramesh Chandra","doi":"10.1002/asia.202500059","DOIUrl":null,"url":null,"abstract":"<p>The six mononuclear Schiff's base Ru(III) complexes viz., [Ru(BZP)(LA)<sub>2</sub>].2NO<sub>3</sub> (MRA), [Ru(BZP)(LB)<sub>2</sub>].2NO<sub>3</sub> (MRB), [Ru(BZP))(LC)<sub>2</sub>].2NO<sub>3</sub> (MRC), [Ru(BZP))(LD)<sub>2</sub>].2NO<sub>3</sub> (MRD), [Ru(BZP)(LE)<sub>2</sub>].2NO<sub>3</sub> (MRE) and [Ru(BZP)(LF)<sub>2</sub>].2NO<sub>3</sub> (MRF), were synthesized using of (BZP=2,6-bis(2-benzimidazolyl)pyridine and <i>p</i>-sub-benzylthiosemicarbazones (BTS) [(Sub=4-NO<sub>2</sub> (LA), 4-N(CH<sub>3</sub>)<sub>2</sub> (LB), 4-Cl (LC), 4-OCH<sub>3</sub> (LD), 4-OCH<sub>2</sub>Ph (LE), and 4-OH (LF)] as an ancillary ligands. The thiosemicarbazones ligands (LA-LF) were obtained by the condensation of <i>p</i>-substituted benzaldehyde and thiosemicarbazide. These complexes were characterized by elemental analysis, IR, ESR, ESI-MS, electronic absorption spectroscopy. The geometry was optimized by theoretical calculation using DFT and structure reveals that MRA-MRF adopt octahedral geometry. Further, the complexes were examined for anti-cancer against Leukemia cancer cell line K562 and shown significant responses to these cells. Moreover, DNA binding studies were conducted with all complexes MRA-MRF and the binding constant (K<sub>b</sub>) were found i.e., 1.10×10<sup>4</sup>, 1.54×10<sup>4</sup>, 2.87×10<sup>4</sup>, 1.67×10<sup>4</sup>, 1.98×10<sup>4</sup> and 1.59×10<sup>4</sup>, respectively. It was found that DNA binds in intercalation mode which is also validated by the docking studies.</p>","PeriodicalId":145,"journal":{"name":"Chemistry - An Asian Journal","volume":"20 8","pages":""},"PeriodicalIF":3.3000,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"New Ru(III) 2,6-Bis(2-Benzimidazolyl)Pyridine Complexes Bearing P-Sub-Benzyl Thiosemicarbazones Schiff Base: Synthesis, Characterization, DNA Binding and Anti-cancer Activity\",\"authors\":\"Ashok K. Singh, Ravindra K. Singh, Kumud Pandav, Swaila Bano, Farha Arshi, Amarendra Kumar, Sudheer Kumar Singh, Ramesh Chandra\",\"doi\":\"10.1002/asia.202500059\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>The six mononuclear Schiff's base Ru(III) complexes viz., [Ru(BZP)(LA)<sub>2</sub>].2NO<sub>3</sub> (MRA), [Ru(BZP)(LB)<sub>2</sub>].2NO<sub>3</sub> (MRB), [Ru(BZP))(LC)<sub>2</sub>].2NO<sub>3</sub> (MRC), [Ru(BZP))(LD)<sub>2</sub>].2NO<sub>3</sub> (MRD), [Ru(BZP)(LE)<sub>2</sub>].2NO<sub>3</sub> (MRE) and [Ru(BZP)(LF)<sub>2</sub>].2NO<sub>3</sub> (MRF), were synthesized using of (BZP=2,6-bis(2-benzimidazolyl)pyridine and <i>p</i>-sub-benzylthiosemicarbazones (BTS) [(Sub=4-NO<sub>2</sub> (LA), 4-N(CH<sub>3</sub>)<sub>2</sub> (LB), 4-Cl (LC), 4-OCH<sub>3</sub> (LD), 4-OCH<sub>2</sub>Ph (LE), and 4-OH (LF)] as an ancillary ligands. The thiosemicarbazones ligands (LA-LF) were obtained by the condensation of <i>p</i>-substituted benzaldehyde and thiosemicarbazide. These complexes were characterized by elemental analysis, IR, ESR, ESI-MS, electronic absorption spectroscopy. The geometry was optimized by theoretical calculation using DFT and structure reveals that MRA-MRF adopt octahedral geometry. Further, the complexes were examined for anti-cancer against Leukemia cancer cell line K562 and shown significant responses to these cells. Moreover, DNA binding studies were conducted with all complexes MRA-MRF and the binding constant (K<sub>b</sub>) were found i.e., 1.10×10<sup>4</sup>, 1.54×10<sup>4</sup>, 2.87×10<sup>4</sup>, 1.67×10<sup>4</sup>, 1.98×10<sup>4</sup> and 1.59×10<sup>4</sup>, respectively. 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New Ru(III) 2,6-Bis(2-Benzimidazolyl)Pyridine Complexes Bearing P-Sub-Benzyl Thiosemicarbazones Schiff Base: Synthesis, Characterization, DNA Binding and Anti-cancer Activity
The six mononuclear Schiff's base Ru(III) complexes viz., [Ru(BZP)(LA)2].2NO3 (MRA), [Ru(BZP)(LB)2].2NO3 (MRB), [Ru(BZP))(LC)2].2NO3 (MRC), [Ru(BZP))(LD)2].2NO3 (MRD), [Ru(BZP)(LE)2].2NO3 (MRE) and [Ru(BZP)(LF)2].2NO3 (MRF), were synthesized using of (BZP=2,6-bis(2-benzimidazolyl)pyridine and p-sub-benzylthiosemicarbazones (BTS) [(Sub=4-NO2 (LA), 4-N(CH3)2 (LB), 4-Cl (LC), 4-OCH3 (LD), 4-OCH2Ph (LE), and 4-OH (LF)] as an ancillary ligands. The thiosemicarbazones ligands (LA-LF) were obtained by the condensation of p-substituted benzaldehyde and thiosemicarbazide. These complexes were characterized by elemental analysis, IR, ESR, ESI-MS, electronic absorption spectroscopy. The geometry was optimized by theoretical calculation using DFT and structure reveals that MRA-MRF adopt octahedral geometry. Further, the complexes were examined for anti-cancer against Leukemia cancer cell line K562 and shown significant responses to these cells. Moreover, DNA binding studies were conducted with all complexes MRA-MRF and the binding constant (Kb) were found i.e., 1.10×104, 1.54×104, 2.87×104, 1.67×104, 1.98×104 and 1.59×104, respectively. It was found that DNA binds in intercalation mode which is also validated by the docking studies.
期刊介绍：
Chemistry—An Asian Journal is an international high-impact journal for chemistry in its broadest sense. The journal covers all aspects of chemistry from biochemistry through organic and inorganic chemistry to physical chemistry, including interdisciplinary topics.
Chemistry—An Asian Journal publishes Full Papers, Communications, and Focus Reviews.
A professional editorial team headed by Dr. Theresa Kueckmann and an Editorial Board (headed by Professor Susumu Kitagawa) ensure the highest quality of the peer-review process, the contents and the production of the journal.
Chemistry—An Asian Journal is published on behalf of the Asian Chemical Editorial Society (ACES), an association of numerous Asian chemical societies, and supported by the Gesellschaft Deutscher Chemiker (GDCh, German Chemical Society), ChemPubSoc Europe, and the Federation of Asian Chemical Societies (FACS).
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